Table 1 Antibacterial efficacies of C. mongolica root extract, antibiotic, and the combination of both treatments in B. melitensis-infected BALB/c mice

Treatment group

Spleen index (mean ± SD)

Spleen index reduction

Log CFU in 0.1 g spleen (mean ± SD)

Log reduction

Non infected

0.3 ± 0.2

Control

–

Pretreatment

1.09 ± 0.4*

↑0.79

5.46 ± 0.15

Non treatment

0.96 ± 0.2*

↑0.66

4.5 ± 0.1

Control

Doxycycline

0.15 ± 0.01*

↓0.15

2.05 ± 0.07**

2.45

Combination treatment

0.19 ± 0.07*

↓0.11

2.1 ± 0.2**

2.4

C.mongolica root extract

0.32 ± 0.05

↑0.02

3.03 ± 0.15

1.47