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Table 4 Modulation of caspase (-8, -9, -3/7) activity and ATP levels in LPS stimulated and 72 h WRE treated PBMC’s

From: Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

WRE (mg/ml) Caspase-8 (RLU ×  105) Caspase-9 (RLU ×  105) Caspase-3/7 (RLU ×  105) ATP (RLU ×  105)
Control 42.651 ± 0.039 115.041 ± 3.848 155.556 ± 0.387 20.574 ± 0.316
0.05 53.840 ± 0.026 *** 143.861 ± 3.929 *** 196.471 ± 0.338 *** 10.223 ± 0.046 ***
0.1 52.109 ± 0.009 *** 129.033 ± 0.289 *** 192.695 ± 0.233 *** 12.506 ± 0.373 ***
0.2 42.751 ± 0.039 ** 105.494 ± 4.247 ** 154.203 ± 0.224 *** 13.210 ± 0.043 ***
0.4 29.656 ± 0.007 *** 92.718 ± 0.021 *** 165.139 ± 0.096 *** 13.361 ± 0.279 ***
  1. (Values expressed as mean ± SD,** p < 0.005, *** p < 0.0001 compared to the control)