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Table 3 Modulation of caspase (-8, -9, -3/7) activity and ATP levels in LPS stimulated and 24 h WRE treated THP-1 cells

From: Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

WRE (mg/ml) Caspase-8 (RLU ×  105) Caspase-9 (RLU ×  105) Caspase-3/7 (RLU ×  105) ATP (RLU ×  105)
Control 10.207 ± 0.011 1.040 ± 0.007 1.251 ± 0.016 2.636 ± 0.011
0.05 8.440 ± 0.039 *** 2.365 ± 0.005 *** 1.315 ± 0.005 *** 3.726 ± 0.005 ***
0.1 2.413 ± 0.005 *** 2.459 ± 0.002 *** 2.294 ± 0.006 *** 5.132 ± 0.014 ***
0.2 7.149 ± 0.027 *** 0.775 ± 0.002 *** 3.406 ± 0.006 *** 29.838 ± 0.186 ***
0.4 2.456 ± 0.033 *** 3.197 ± 0.0001 *** 9.428 ± 0.004 *** 10.282 ± 0.195 ***
  1. (Values expressed as mean ± SD, *** p < 0.0001 compared to the control)