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Table 2 Modulation of caspase (-8, -9, -3/7) activity and ATP levels in LPS stimulated and 24 h WRE treated PBMC’s

From: Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

WRE (mg/ml) Caspase-8 (RLU ×  105) Caspase-9 (RLU ×  105) Caspase-3/7 (RLU ×  105) ATP (RLU ×  105)
Control 0.185 ± 0.006 0.366 ± 0.0003 7.756 ± 0.006 4.714 ± 0.004
0.05 0.155 ± 0.0002 *** 0.376 ± 0.001 *** 8.109 ± 0.094 ** 2.783 ± 0.017 ***
0.1 0.192 ± 0.00002 0.253 ± 0.0002 *** 11.504 ± 0.253 *** 5.208 ± 0.005 ***
0.2 0.246 ± 0.0003 *** 0.397 ± 0.0005 *** 8.961 ± 0.015 *** 3.741 ± 0.033 ***
0.4 4.814 ± 0.006 *** 0.351 ± 0.001 *** 17.095 ± 0.089 *** 6.965 ± 0.039 ***
  1. (Values expressed as mean ± SD, ** p < 0.005, *** p < 0.0001 compared to the control)