Potentiating and synergistic effect of grapefruit juice on the antioxidant and anti-inflammatory activity of aripiprazole against hydrogen peroxide induced oxidative stress in mice

Table 2 Effect of H₂O_2, GFJ, ARI induced alterations alone and in combination, on the levels of enzymatic and non-enzymatic antioxidant contents in serum of control and treated mice

Treatment Groups	Group I Control	Group II H₂O₂	Group III GF	Group IV ARI	Group V GF+ H₂O₂	Group VI ARI+ H₂O₂	Group VII ARI + GF + H₂O₂
ALT (U/ml)	40.07 ± 2.70	103.3 ± 3.40^*	36.98 ± 3.30	38.03 ± 3.90	69.42 ± 4.29 ^*#	49.98 ± 3.43^*#	38.99 ± 3.29^#
Protein (mg /ml)	4.45 ± 0.90	2.08 ± 0.20^*	4.12 ± 0.19	4.57 ± 0.10	3.70 ± 0.70^*#	4.38 ± 0.30^#	4.98 ± 0.21^#
BUN (mg/dl)	43.07 ± 2.69	129.6 ± 4.10^*	41.50 ± 3.40	38.06 ± 2.80	73.86 ± 3.67 ^*#	56.50 ± 2.85^*#	40.31 ± 3.28^#
Creatinine (mg/dl)	0.32 ± 0.03	0.58 ± 0.07^*	0.385 ± 0.06	0.285 ± 0.01	0.48 ± 0.08^*#	0.45 ± 0.04^*#	0.41 ± 0.06^#
CK (U/ml)	66.66 ± 5.30	52.6 ± 7.80^*	63.12 ± 5.20	68.28 ± 3.60	69.9 ± 8.70^#	71.9 ± 6.30^#	60.53 ± 4.9

* Statistically significant when compared to control group (P < 0.0001)
^#Statistically significant when compared to H₂O₂ treated group (P < 0.0001)
Data presented as (mean ± SE) of three independent experiments and No. of animals (n = 10)

ISSN: 2662-7671