|
Groups
|
Urinary concentrations (mEq/L)
|
|---|
|
Na+
|
Cl−
|
K+
|
Ca2+
|
|---|
|
Control
|
70.50 ± 6.05
|
81.20 ± 3.10
|
52.20 ± 2.01
|
1.80 ± 0.10
|
|
EFPA (10 mg/kg)
|
90.00 ± 4.70*
|
97.33 ± 2.90*
|
36.70 ± 1.63*
|
1.73 ± 0.10
|
|
EFPA (10 mg/kg) + Indomethacin (5 mg/kg)
|
43.50 ± 4.43*,#
|
96.70 ± 4.10*
|
61.00 ± 2.42*,#
|
3.10 ± 0.20
|
- Rats were treated over a 24 h period with a single dose of vehicle (control group), EFPA (10 mg/kg) or EFPA (10 mg/kg) + indomethacin (5 mg/kg, 1 h pretreatment) administered i.p. Data are given as means ± SEM of 6 different experiments. Statistical analyses were assessed using two-way analysis of variance (ANOVA) followed by Bonferroni’s post- test. *p < 0.05 versus control, and #p < 0.05 versus EFPA
