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Table 2 Inhibitory effect of indomethacin on urinary electrolyte excretion induced by EFPA in rats

From: The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins

Groups Urinary concentrations (mEq/L)
Na+ Cl K+ Ca2+
Control 70.50 ± 6.05 81.20 ± 3.10 52.20 ± 2.01 1.80 ± 0.10
EFPA (10 mg/kg) 90.00 ± 4.70* 97.33 ± 2.90* 36.70 ± 1.63* 1.73 ± 0.10
EFPA (10 mg/kg) + Indomethacin (5 mg/kg) 43.50 ± 4.43*,# 96.70 ± 4.10* 61.00 ± 2.42*,# 3.10 ± 0.20
  1. Rats were treated over a 24 h period with a single dose of vehicle (control group), EFPA (10 mg/kg) or EFPA (10 mg/kg) + indomethacin (5 mg/kg, 1 h pretreatment) administered i.p. Data are given as means ± SEM of 6 different experiments. Statistical analyses were assessed using two-way analysis of variance (ANOVA) followed by Bonferroni’s post- test. *p < 0.05 versus control, and #p < 0.05 versus EFPA