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Table 3 MMSE change among AD patients with different severities

From: Adding Chinese herbal medicine to conventional therapy brings cognitive benefits to patients with Alzheimer’s disease: a retrospective analysis

  MMSE change
6 m 12 m 18 m 24 m
Mild (MMSE 21–26)
 CT + H mean ± SE 0.03 ± 0.42 −0.15 ± 0.47 −1.21 ± 0.40 −0.06 ± 0.48
95% CI −0.83 to 0.88 −1.12 to 0.81 −2.09 to −0.33 −1.1 to 0.97
N 36 32 14 15
 CT mean ± SE −0.16 ± 0.75 0.13 ± 0.83 −2.66 ± 0.77 −2.66 ± 0.73
95% CI −1.75 to 1.41 −1.66 to 1.93 −4.36 to −0.96 −4.27 to −1.05
N 18 15 11 12
P value 0.043 0.660 0.030 0.012
Moderate (MMSE 10–20)
 CT + H mean ± SE 1.5 ± 0.63 0.46 ± 0.91 −1.9 ± 0.7 −2.84 ± 0.61
95% CI 0.21 to 2.78 −1.49 to 2.42 −3.49 to −0.3 −4.19 to −1.49
N 28 15 10 13
 CT mean ± SE 1.14 ± 0.68 −2.38 ± 0.67 −3.6 ± 0.42 −5 ± 0.34
95% CI −0.34 to 2.62 −3.85 to −0.91 −4.5 to −2.69 −5.75 to −4.24
N 14 13 15 14
P value 0.196 0.001 0.253 0.025
  1. As severe cases were few, the analysis were done only in mild and moderate AD patients. Differences between CT + H and CT were observed at 12 to 24 months in moderate group, but later at 24 months in mild group. MMSE denotes mini-mental state examination; CT + H denotes conventional therapy with herbal medicine; CT denotes conventional therapy alone