Fig. 1

Experimental design. Baseline sucrose-preference was assessed before beginning the chronic unpredictable mild stress (CUMS). Only the animals having reduced the preference for sucrose by more than 50% were selected for the next steps of the experiment. F. sycomorus extract or imipramine was administered daily by gavage during both the 30 days stress sessions and behavior tests. At the end of the stress period, behavioral tests were carried out in a growing of stress order. The same set of animals was used for all the behavioral tests: day 31 for NSF, EPM, Y-maze and days 32, 33 for FST. Following the FS test, the mice were sacrificed for biochemical assay