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Table 3 Antioxidant activity of MMMC against ethanol-induced gastric ulcer in stomach tissue of rats 

From: Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats

Pre-treatment Ratio Dose (mg/kg) CAT (nmol/min/mL) SOD (U/mg protein) GSH (μM/mg protein) MDA (ng/mL)
Normal   60.47 ± 2.251 4.72 ± 0.364 43.28 ± 1.118 11.42 ± 0.577
2% Tween 80   44.11 ± 1.591*** 1.56 ± 0.240*** 6.606 ± 1.175*** 75.00 ± 1.732***
Ranitidine   100 66.11 ± 1.569*** 3.20 ± 0.381* 23.68 ± 1.037*** 15.00 ± 1.693***
MMMC 1:1 15 66.27 ± 1.439*** 2.60 ± 0.469* 35.61 ± 1.651*** 33.07 ± 2.214***
150 67.01 ± 1.579*** 3.94 ± 0.351*** 35.80 ± 0.578*** 31.44 ± 1.605***
300 69.54 ± 1.846*** 3.96 ± 0.365*** 38.48 ± 0.955*** 26.21 ± 1.707***
1:3 15 68.09 ± 1.932*** 2.70 ± 0.327* 39.46 ± 1.878*** 46.11 ± 0.824**
150 66.58 ± 2.120*** 3.65 ± 0.222*** 38.47 ± 0.716*** 36.11 ± 1.883***
300 63.51 ± 2.016** 3.46 ± 0.361** 30.49 ± 1.280*** 35.83 ± 2.455***
3:1 15 69.03 ± 1.449*** 2.66 ± 0.372* 32.27 ± 1.196*** 63.06 ± 2.544*
150 68.33 ± 1.456*** 3.79 ± 0.329*** 42.22 ± 0.705*** 41.11 ± 1.321***
300 64.51 ± 1.965** 3.82 ± 0.362*** 33.36 ± 1.224*** 38.22 ± 1.833***
  1. Data are presented as mean ± S.E.M. Sixty rats (n = 6 in each group) were used in this study. Statistical analysis was performed
  2. using the one-way ANOVA followed by Dunnet’s multiple comparison tests. *P < 0.05,**P < 0.01 and ***P < 0.001 as compared to ulcer control group