Fig. 9

Hierarchical clustering heatmap of the Log2 relative fold-changes calculated for all taxonomic groups (family and genus levels). (a) Both taxa and treatment groups were subject to HCL analysis. (b) Shows a detail of the results for the groups’ HCL. The KMC analysis roughly revealed the presence of 7 major clusters (C1-C7) based on similarly of taxa relative fold-changes. Legend: C, cluster; E, Epicor; M, moderate subgroup, P, placebo; S, severe subgroup; TC, total cohort; V, visit