Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced diabetic rats

Table 3 Effect of ethanolic extract of E. hirta whole plant on excision wound in alloxan induced diabetic rats

Group/ Post wounding days	Wound area (cm²)					% of wound contraction at the end of the study
Group/ Post wounding days	1st day	4th day	8th day	12th day	16th day
Group I	N/A	N/A	N/A	N/A	N/A	N/A
Group II	4.90 ± 1.13	4. 90 ± 1.20	4.85 ± 0.88	4.72 ± 0.89	4.60 ± 0.93	6.12
Group III	4.90 ± 1.11	4.83 ± 1.05^†	4.58 ± 1.17^†	3.76 ± 0.59^†	3.14 ± 0.36^†	35.92
Group IV	4.90 ± 1.03	4.70 ± 0.91^†	4.50 ± 0.86^†	3.23 ± 0.65^†	2.71 ± 0.40^*	44.69
Group V	4.90 ± 1.10	4.58 ± 1.07^†	4.16 ± 0.88^†	2.48 ± 0.33^*	1.89 ± 0.35^**	61.42
Group VI	4.90 ± 1.12	4.51 ± 1.01^†	4.35 ± 0.76^†	3.26 ± 0.33^†	2.95 ± 0.54^*	39.79
Group VII	4.90 ± 1.16	4.83 ± 1.21^†	4.55 ± 0.73^†	3.92 ± 0.58^†	3.29 ± 0.37^†	32.86
Group VIII	4.90 ± 0.88	4.75 ± 1.03^†	4.47 ± 0.68^†	3.41 ± 0.56^†	3.12 ± 0.49^†	36.32

Each value is Mean ± S.E.M (n = 3). (*) indicates statistically significant difference from the diabetic wound control using ANOVA, followed by Dunnett’s multiple comparison test (^** p < 0.01). (†) indicates statistically no significant difference from the diabetic wound control using ANOVA, followed by Dunnett’s multiple comparison test (p > 0.05). Group I = normal control, Group II = Diabetic wound control, Group III = Diabetic wound control +100 mg ethanolic extract of E. hirta, Group IV = Diabetic wound control +200 mg ethanolic extract of E. hirta, Group V = Diabetic wound control +400 mg ethanolic extract of E. hirta, Group VI = Diabetic wound control +5% Povidone iodine, Group VII = Diabetic wound control +5% ethanolic extract of E. hirta, Group VIII = Diabetic wound control +10% ethanolic extract of E. hirta

ISSN: 2662-7671