Table 3 Effect of different test doses of product on hematological parameters in male & female rats
From: Acute and sub-acute toxicity study of a Pakistani polyherbal formulation
Parameters | Males | Females | ||||||
|---|---|---|---|---|---|---|---|---|
Control | 50 mg/kg/day | 100 mg/kg/day | 200 mg/kg/day | Control | 50 mg/kg/day | 100 mg/kg/day | 200 mg/kg/day | |
WBCs (10*3/ul) | 4.91 ± 0.245 | 4.97 ± 0.141 | 5.79* ± 0.144 | 6.14** ± 0.143 | 2.642 ± 0.137 | 3.102 ± 1.090 | 3.350 ± 1.174 | 3.232 ± 1.128 |
RBCs (10*6/ul) | 6.80 ± 0.178 | 6.33 ± 0.152 | 7.18 ± 0.141 | 6.28 ± 0.212 | 7.596 ± 0.83 | 7.214 ± 0.210 | 7.870 ± 0.197 | 7.544 ± 0.227 |
PLT (10*3/ul) | 643.804 ± 2.429 | 644.09 ± 1.432 | 644.496 ± 1.373 | 654.26** ± 1.314 | 682.582 ± 1.928 | 675.50 ± 1.496 | 683.794 ± 1.941 | 667.068** ± 1.594 |
Hb (g/dl) | 12.028 ± 0.218 | 12.038 ± 0.166 | 11.076 ± 0.143 | 10.972* ± 0.306 | 12.55 ± 0.240 | 12.66 ± 0.278 | 13.156 ± 0.306 | 13.052 ± 0.370 |
HCT (%) | 40.066 ± 0.437 | 40.422 ± 0.338 | 40.172 ± 0.473 | 39.962 ± 0.337 | 38.276 ± 0.395 | 37.696 ± 0.505 | 38.726 ± 0.433 | 38.33 ± 0.561 |
MCV(fl) | 76.020 ± 0.443 | 75.456 ± 0.432 | 75.728 ± 0.362 | 75.582 ± 0.310 | 74.302 ± 0.440 | 73.822 ± 0.532 | 73.926 ± 0.850 | 75.094 ± 0.820 |
MCH (pg) | 20.788 ± 0.454 | 20.396 ± 0.289 | 20.242 ± 0.336 | 20.332 ± 0.371 | 21.716 ± 0.535 | 21.168 ± 0.295 | 21.048 ± 0.325 | 21.168 ± 0.567 |
MCHC (g/dl) | 40.368 ± 0.400 | 40.610 ± 0.244 | 40.544 ± 0.237 | 40.468 ± 0.355 | 41.142 ± 0.358 | 41.574 ± 0.527 | 41.404 ± 0.621 | 41.126 ± 0.452 |