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Table 1 Effect of B.orthobotrys on turpentine oil induced joint edema in rats (n = 5, Mean ± SEM)

From: Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch

Treatment groups Increase in joint diameter (mm)
1 h 2 h 3 h 4 h 5 h 6 h
Arthritic control
(3 ml/kg)
9.44 ± 0.028 10.59 ± 0.022 12.34 ± 0.023 14.98 ± 0.027 16.38 ± 0.028 20.96 ± 0.028
Standard Aspirin
(100 mg/kg)
7.02 ± 0.026***
(25.63)
6.83 ± 0.026***
(35.50)
6.58 ± 0.035***
(46.67)
6.37 ± 0.024***
(57.34)
6.25 ± 0.028***
(61.84)
6.02 ± 0.027***
(71.27)
Aqueous-methanolic extract (50 mg/kg) 7.40 ± 0.021***
(21.61)
7.15 ± 0.021***
(32.48)
6.95 ± 0.030***
(43.67)
6.87 ± 0.026***
(54.13)
6.71 ± 0.026***
(59.03)
6.63 ± 0.024***
(68.36)
Aqueous-methanolic extract (100 mg/kg) 7.19 ± 0.021***
(23.83)
6.87 ± 0.027***
(35.12)
6.61 ± 0.022***
(46.43)
6.54 ± 0.021***
(56.34)
6.33 ± 0.026***
(61.35)
6.10 ± 0.024***
(70.89)
Aqueous-methanolic extract (150 mg/kg) 6.84 ± 0.026***
(27.54)
6.58 ± 0.025***
(37.86)
6.31 ± 0.024***
(48.86)
6.14 ± 0.022***
(59.01)
5.82 ± 0.023***
(64.46)
5.50 ± 0.025***
(73.75)
n-butanol fraction (50 mg/kg) 7.75 ± 0.018***
(17.90)
7.68 ± 0.019***
(27.47)
8.33 ± 0.024***
(32.49)
8.29 ± 0.029***
(44.65)
8.24 ± 0.029***
(49.69)
8.19 ± 0.027***
(60.92)
n-butanol fraction (100 mg/kg) 7.51 ± 0.023***
(20.44)
7.48 ± 0.023***
(29.36)
7.84 ± 0.021***
(36.46)
7.76 ± 0.027***
(48.19)
7.70 ± 0.025***
(52.99)
7.65 ± 0.019***
(63.50)
n-butanol fraction
(150 mg/kg)
7.32 ± 0.021***
(22.45)
7.20 ± 0.021***
(32.01)
7.39 ± 0.021***
(40.11)
7.21 ± 0.021***
(51.86)
7.04 ± 0.028***
(57.02)
6.90 ± 0.023***
(67.08)
Ethyl acetate fraction
(50 mg/kg)
7.96 ± 0.029***
(15.67)
7.86 ± 0.028***
(25.77)
8.44 ± 0.028***
(31.60)
8.41 ± 0.031***
(43.85)
8.05 ± 0.020***
(50.85)
9.10 ± 0.023***
(56.58)
Ethyl acetate fraction
(100 mg/kg)
7.74 ± 0.021***
(18.00)
7.71 ± 0.026***
(27.19)
7.96 ± 0.027***
(35.49)
7.80 ± 0.028***
(47.93)
7.75 ± 0.025***
(52.68)
8.40 ± 0.021***
(59.92)
Ethyl acetate fraction
(150 mg/kg)
7.43 ± 0.027***
(21.29)
7.40 ± 0.026***
(30.12)
7.73 ± 0.021***
(37.35)
7.48 ± 0.017***
(50.06)
7.22 ± 0.025***
(55.92)
7.70 ± 0.030***
(63.26)
Aqueous fraction
(50 mg/kg)
8.24 ± 0.023***
(12.71)
8.11 ± 0.026***
(23.41)
8.60 ± 0.026***
(30.30)
8.92 ± 0.030***
(40.25)
9.13 ± 0.027***
(44.26)
9.58 ± 0.025***
(54.29)
Aqueous fraction
(100 mg/kg)
7.98 ± 0.024***
(15.46)
7.77 ± 0.026***
(26.62)
8.10 ± 0.026***
(34.35)
8.45 ± 0.027***
(43.59)
7.78 ± 0.023***
(52.50)
8.99 ± 0.025***
(57.10)
Aqueous fraction
(150 mg/kg)
7.62 ± 0.021***
(19.27)
7.54 ± 0.021***
(28.80)
7.69 ± 0.028***
(37.68)
7.95 ± 0.023***
(46.92)
7.23 ± 0.033***
(55.86)
8.30 ± 0.027***
(60.40)
  1. Values in the parenthesis represent percentage inhibition of paw edema. The statistical analysis was carried out using two way ANOVA followed by Bonferroni posttest. *** = p < 0.001 when compared to arthritic control