Centella asiatica modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

Table 3 Modulation of caspase (−8, −9, −3/7) activities and ATP levels in 24 h C_LE treated THP-1 cells

C_LE (mg/ml)	Caspase-8 (RLU × 10⁵)	Caspase-9 (RLU × 10⁵)	Caspase-3/7 (RLU × 10⁵)	ATP (RLU × 10⁵)
Control	8.517 ± 0.001	1.933 ± 0.012	9.980 ± 0.008	17.551 ± 0.088
0.05	11.494 ± 0.006^***	0.415 ± 0.002^***	10.348 ± 0.218^**	12.507 ± 0.398^***
0.2	18.909 ± 0.085^***	0.675 ± 0.001^***	3.974 ± 0.001^***	15.586 ± 0.215^***
0.4	12.276 ± 0.028^***	1.119 ± 0.003^***	4.046 ± 0.033^***	3.948 ± 0.042^***
0.8	16.191 ± 0.013^***	2.261 ± 0.002^***	18.189 ± 0.104^***	19.496 ± 0.267^***

(Values expressed as mean ± SD, ^** p < 0.001, ^*** p < 0.0001 compared to the control)

ISSN: 2662-7671