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Table 9 Effect of Cynara scolymus leaves extracts on liver-kidney dysfunction of experimental groups of rats

From: Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats

Groups of treatment Cont Diab Diab + Ethanol extract of leaves C. scolymus (200 mg /kg) Diab + Ethanol extract of leaves C. scolymus (400 mg/kg) Diab + Acarbose (12 mg/kg)
AST (UI/L) 106.6 ± 1.19 158.25 ± 7.67*** 90.25 ± 2.82### 95.14 ± 2.47### 101.66 ± 3.17###
ALT (UI/L) 35.33 ± 5.68 60.25 ± 8.18*** 31.00 ± 4.64###£ 35.16 ± 8.42### 37.75 ± 5.73###
ALP (UI/L) 150.5 ± 1.57 200.8 ± 2.5*** 180.00 ± 2.64### 186.25 ± 1.81### 175.14 ± 1.64###
Albumin (g/l) 35.40 ± 1.50 40 ± 0.78*** 30.57 ± 1.17# 32.4 ± 0.46### 30.2 ± 0.50###
Urea (mmol/L) 4.76 ± 0.57 7.64 ± 0.89** 6.41 ± 0.93### 4.76 ± 0.57###£££ 6.98 ± 1.26ns
Creatinine (umol/L) 14.64 ± 3.54 26.84 ± 3.77*** 17.50 ± 3.39###£ 19.66 ± 1.00## 19.51 ± 5.25###
  1. Diabetic rats were orally administered with ethanol extract from leaves of C. scolymus and acarbose at the doses mentioned earlier for 28 days. Values are given as means ± SD (n = 8). ** p ≤ 0.01, *** p ≤ 0.001 were considered significant compared to control group; # p ≤ 0.05, ### p ≤ 0.001 were considered significant compared to diabetic rat.; £ p ≤ 0.05, £££ p ≤ 0.001 compared to diabetic rats treated with acarbose. ns: non-significant changes between diabetic treated groups vs. the control group after 28 days treatment