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Table 8 Effect of Cynara scolymus leaves extracts on plasma lipid profile levels of experimental groups of rats

From: Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats

Lipid profile Control Diab Diab + Ethanol extract of leaves C. scolymus (200 mg/kg) Diab + Ethanol extract of leaves C. scolymus (400 mg/kg) Diab + Acarbose (12 mg/kg)
TG (mmol/L) 0.57 ± 0.06 1.51 ± 0.36*** 0.6 ± 0.05### 0.54 ± 0.05### 0.64 ± 0.07###
T-Ch (mmol/L) 1.45 ± 0.26 1.83 ± 0.11* 1.59 ± 0.05#£££ 1.67 ± 0.06#£££ 1.28 ± 0.20###
LDL-c (mmol/L) 0.49 ± 0.17 0.9 ± 0.08*** 0.56 ± 0.15### 0.6 ± 0.10### 0.55 ± 0.21###
HDL-c (mmol/L) 0.52 ± 0.07 0.27 ± 0.01*** 0.47 ± 0.03###£ 0.50 ± 0.07###£ 0.33 ± 0.04###
HTR (%) 23.05 ± 5.88 15.69 ± 0.50* 26.69 ± 1.82### 29.53 ± 3.21### 28.10 ± 3.27###
AI 2.00 ± 0.07 3.83 ± 0.74*** 2.54 ± 0.20# 2.4 ± 0.39# 2.58 ± 0.44#
LDL-c/HDL-c 1.28 ± 0.15 2.32 ± 0.15*** 2.11 ± 0.09# 1.6 ± 1.10### 1.73 ± 0.41#
  1. Diabetic rats were orally administered with ethanol extract from leaves of C. scolymus and acarbose at the doses mentioned earlier for 28 days. Values are given as means ± SD (n = 8). * p ≤ 0.05, *** p ≤ 0.001 were considered significant compared to control group; # p ≤ 0.05, ### p ≤ 0.001 were considered significant compared to diabetic rat.; £ p ≤ 0.05, £££ p ≤ 0.001 compared to diabetic rats treated with acarbose, ns: non-significant changes between diabetic treated groups vs. the control group after 28 days treatment. AI = (T-Ch-HDL-c)/HDL-c, HTR (%) = HDL-C/T-Ch ratio