Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats

Table 8 Effect of Cynara scolymus leaves extracts on plasma lipid profile levels of experimental groups of rats

Lipid profile	Control	Diab	Diab + Ethanol extract of leaves C. scolymus (200 mg/kg)	Diab + Ethanol extract of leaves C. scolymus (400 mg/kg)	Diab + Acarbose (12 mg/kg)
TG (mmol/L)	0.57 ± 0.06	1.51 ± 0.36^***	0.6 ± 0.05^###	0.54 ± 0.05^###	0.64 ± 0.07^###
T-Ch (mmol/L)	1.45 ± 0.26	1.83 ± 0.11^*	1.59 ± 0.05^#£££	1.67 ± 0.06^#£££	1.28 ± 0.20^###
LDL-c (mmol/L)	0.49 ± 0.17	0.9 ± 0.08^***	0.56 ± 0.15^###	0.6 ± 0.10^###	0.55 ± 0.21^###
HDL-c (mmol/L)	0.52 ± 0.07	0.27 ± 0.01^***	0.47 ± 0.03^###£	0.50 ± 0.07^###£	0.33 ± 0.04^###
HTR (%)	23.05 ± 5.88	15.69 ± 0.50^*	26.69 ± 1.82^###	29.53 ± 3.21^###	28.10 ± 3.27^###
AI	2.00 ± 0.07	3.83 ± 0.74^***	2.54 ± 0.20^#	2.4 ± 0.39^#	2.58 ± 0.44^#
LDL-c/HDL-c	1.28 ± 0.15	2.32 ± 0.15^***	2.11 ± 0.09^#	1.6 ± 1.10^###	1.73 ± 0.41^#

Diabetic rats were orally administered with ethanol extract from leaves of C. scolymus and acarbose at the doses mentioned earlier for 28 days. Values are given as means ± SD (n = 8). ^* p ≤ 0.05, ^*** p ≤ 0.001 were considered significant compared to control group; ^# p ≤ 0.05, ^### p ≤ 0.001 were considered significant compared to diabetic rat.; ^£ p ≤ 0.05, ^£££ p ≤ 0.001 compared to diabetic rats treated with acarbose, ^ns: non-significant changes between diabetic treated groups vs. the control group after 28 days treatment. AI = (T-Ch-HDL-c)/HDL-c, HTR (%) = HDL-C/T-Ch ratio

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