Fig. 3

Liver photomicrographs. a) Normal architecture of liver showed the central vein (CV) and hepatocytes (H). b) APAP- treated group, showed necrosis of the hepatocytes (N), steatosis (S) and also infiltration the inflammatory cells (IL). c) APAP- induced after pre-treatment with 200 mg/kg of Silymarin showed normal architecture of hepatocytes with mild microsteatosis. d) Pre-treatment with 50 mg/kg of MEDL also attenuated the histopathological changes by the APAP- induced hepatotoxicity showed mild steatosis. e) Pre-treatment with 250 mg/kg of MEDL showed moderate necrosis of the hepatocytes. f) APAP-induced hepatotoxic liver after pre-treatment with 500 mg/kg MEDL showing mild steatosis