Skip to main content

Table 9 Effects of fenchone and 5-FU on hematological parameters of peripheral blood of mice (n = 6) subjected to different treatments (9 days)

From: Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Parameters Healthy animals Tumor control 5-FU Fenchone
    25 mg/kg 30 mg/kg 60 mg/kg
Red blood cells, 106/mm3 9.3 ± 0.1 5.8 ± 0.4b 9.7 ± 0.2a 6.9 ± 0.4b,c 8.0 ± 0.4a
Hemoglobin, g/dL 14.8 ± 0.2 9.4 ± 0.6b 14.9 ± 0.4a 12.0 ± 0.33a,b,c 13.3 ± 0.6
Hematocrit, % 43.8 ± 0.5 29.0 ± 1.8b 46.6 ± 1.0a 40.2 ± 0.9a 45.2 ± 3.3a
MCV, fm3 46.6 ± 1.0 49.8 ± 0.6 49.0 ± 0.6 59.0 ± 3.5a,b,c 59.2 ± 2.2a,b,c
MCH, pg 15.8 ± 0.5 16.0 ± 0.1 15.4 ± 0.2 17.2 ± 0.2 a,b,c 16.6 ± 0.3
MCHC, g/dL 33.7 ± 0.3 34.5 ± 0.8 31.3 ± 0.2 28.4 ± 0.9 a,b 31.0 ± 0.7
Total leukocytes, 103/mm3 8.1 ± 0.4 15.1 ± 1.1b 3.2 ± 0.1a 20.2 ± 1.4a,b,c 4.0 ± 0.6a
Lymphocytes, % 60.6 ± 4.2 52.4 ± 12.7 90.4 ± 0.9a 41.6 ± 8.4c 64.6 ± 5.6
Neutrophils, % 34.6 ± 4.2 45.4 ± 12.4 7.0 ± 0.7a 52.8 ± 8.6c 30.0 ± .5.4
Monocytes, % 4.4 ± 0.7 2.0 ± 0.5 2.6 ± 0.7 2.0 ± 0.5 1.4 ± 05b
Eosinophils, % 0.4 ± 0.2 0.2 ± 0.2 0.0 ± 0.2 0.0 ± 0.0 0.0 ± 0.0
  1. Data are presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. a p < 0.05 compared to tumor control; b p < 0.05 compared to healthy animals. c p<0,05 compared To the group treated with 25 mg / kg of 5-FU by ANOVA followed by Tukey