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Table 9 Effects of fenchone and 5-FU on hematological parameters of peripheral blood of mice (n = 6) subjected to different treatments (9 days)

From: Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Parameters

Healthy animals

Tumor control

5-FU

Fenchone

   

25 mg/kg

30 mg/kg

60 mg/kg

Red blood cells, 106/mm3

9.3 ± 0.1

5.8 ± 0.4b

9.7 ± 0.2a

6.9 ± 0.4b,c

8.0 ± 0.4a

Hemoglobin, g/dL

14.8 ± 0.2

9.4 ± 0.6b

14.9 ± 0.4a

12.0 ± 0.33a,b,c

13.3 ± 0.6

Hematocrit, %

43.8 ± 0.5

29.0 ± 1.8b

46.6 ± 1.0a

40.2 ± 0.9a

45.2 ± 3.3a

MCV, fm3

46.6 ± 1.0

49.8 ± 0.6

49.0 ± 0.6

59.0 ± 3.5a,b,c

59.2 ± 2.2a,b,c

MCH, pg

15.8 ± 0.5

16.0 ± 0.1

15.4 ± 0.2

17.2 ± 0.2 a,b,c

16.6 ± 0.3

MCHC, g/dL

33.7 ± 0.3

34.5 ± 0.8

31.3 ± 0.2

28.4 ± 0.9 a,b

31.0 ± 0.7

Total leukocytes, 103/mm3

8.1 ± 0.4

15.1 ± 1.1b

3.2 ± 0.1a

20.2 ± 1.4a,b,c

4.0 ± 0.6a

Lymphocytes, %

60.6 ± 4.2

52.4 ± 12.7

90.4 ± 0.9a

41.6 ± 8.4c

64.6 ± 5.6

Neutrophils, %

34.6 ± 4.2

45.4 ± 12.4

7.0 ± 0.7a

52.8 ± 8.6c

30.0 ± .5.4

Monocytes, %

4.4 ± 0.7

2.0 ± 0.5

2.6 ± 0.7

2.0 ± 0.5

1.4 ± 05b

Eosinophils, %

0.4 ± 0.2

0.2 ± 0.2

0.0 ± 0.2

0.0 ± 0.0

0.0 ± 0.0

  1. Data are presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. a p < 0.05 compared to tumor control; b p < 0.05 compared to healthy animals. c p<0,05 compared To the group treated with 25 mg / kg of 5-FU by ANOVA followed by Tukey