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Table 7 Effects of EOM, fenchone and 5-FU on biochemical parameters of peripheral blood of mice (n=6) subjected to different treatments (9 days)

From: Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Groups Dose, mg/kg AST, U/L ALT, U/L Urea, mg/dL Creatinine, mg/dL
Healthy animals - 283.2 ± 24.9 53.6 ± 6.55 39.0 ± 1.9 0.4 ± 0.0
Tumor control - 242.0 ± 12.2 67,80 ± 7,11 43.0 ± 7.1 0.3 ± 0.0
5-FU 25 199.3 ± 38.4 39.00 ± 9.51 33.2 ± 1.5 0.51 ± 0.02
EOM 50 217.4 ± 27.4 53.8 ± 11,81 27.5 ± 12.0 0.2 ± 0.0
EOM 100 285.4 ± 22.1 60.3 ± 1.43 45.9 ± 5.7 0.2 ± 0.0
EOM 150 320.2 ± 73.9 44.0 ± 6.86 81.8 ± 8.4a,b 0.6 ± 0.2
Fenchone 30 155.8 ± 7.5a,b 29,25 ± 2,68a 38.8 ± 3.8 0.3 ± 0.0
Fenchone 60 163.8 ± 8.5a,b 34.6 ± 5.4a 37.8 ± 2.4 0.2 ± 0.0
  1. Data presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. a p<0.05 compared to tumor control. b p<0.05 compared to healthy animals by ANOVA followed by Tukey