Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Table 5 Feed and water consumption and weight of animals (n = 6) subjected to different treatments (9 days)

Groups	Dose, mg/kg	Water consumption, ml	Feed consumption, g	Gain/loss of weight, %
Healthy animals	-	35.6 ± 1.1	30.9 ± 1.6	12.79 ± 3.0
Tumor control	-	34.6 ± 2.1	29.3 ± 1.5	11.3 ± 1.1
5-FU	25	29.4 ± 1.8	32.8 ± 1.2	−10.1 ± 1.2^a,b
EOM	50	47.2 ± 2.3^a,b	33.9 ± 2.9	17.3 ± 4.7^c
EOM	100	32.5 ± 1.6	30.8 ± 1.6	−8.6 ± 4.3^a,b
EOM	150	29.4 ± 2.7	23.3 ± 2.1^a	−12.9 ± 1.9 ^a,b
Fenchone	30	42.2 ± 1.0^a,b,c	35.6 ± 0.8	5.6 ± 0.9^c
Fenchone	60	46.6 ± 1.6^a,b,c	35.3 ± 0.1	10.23 ± 3.4^c

Data presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. ^a p < 0.05 compared to tumor control. ^b p<0.05 compared to healthy animals. ^c p<0,05 compared to 25 mg/kg 5-FU group by ANOVA followed by Tukey

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