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Table 6 ROC Curve of Interleukin-6, Interferon Gamma, cytochrome P450, Serotonin, Glutamine, Glutamate together with Glutamate/Glutamine ratio in neuro-intoxicated, protected and therapeutically treated rat pups compared to healthy control

From: Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

Parameters Groups Area under the curve Cutoff value Sensitivity % Specificity %
IL-6 (pg\ml) VPA 0.625 9.832 80.0% 40.0%
VPA-CUR 0.740 11.165 90.0% 60.0%
CUR 0.635 12.945 80.0% 50.0%
IFN-γ (pg\ml) VPA 0.750 318.225 90.0% 70.0%
VPA-CUR 0.780 327.520 90.0% 70.0%
CUR 0.805 365.885 100.0% 60.0%
CYP450 (ng\ml) VPA 0.790 37.085 80.0% 80.0%
VPA-CUR 0.590 37.471 50.0% 90.0%
CUR 0.790 37.630 80.0% 90.0%
5HT (ng\ml) VPA 0.620 137.220 60.0% 90.0%
VPA-CUR 0.625 140.965 60.0% 80.0%
CUR 0.550 157.750 50.0% 80.0%
GSTs (mU\ml) VPA 0.620 17.100 90.0% 40.0%
VPA-CUR 0.675 12.450 50.0% 90.0%
CUR 0.730 12.450 60.0% 90.0%
Glutamin (pmol\ml) VPA 0.610 2365.295 90.0% 40.0%
VPA-CUR 0.890 1984.715 90.0% 80.0%
CUR 0.840 2007.865 90.0% 80.0%
Glutamate (nmol\ml) VPA 0.590 244.955 90.0% 50.0%
VPA-CUR 0.645 234.870 70.0% 70.0%
CUR 0.810 213.790 70.0% 100.0%
Glutamate/Glutamin ratio VPA 0.810 0.111 100.0% 60.0%
VPA-CUR 0.820 0.122 80.0% 90.0%
CUR 0.500 0.115 60.0% 70.0%