Parameter | Group | N | Min | Max | Mean ± S.D. | Percent Change | P valuea | P valueb |
---|---|---|---|---|---|---|---|---|
IL-6 (pg\ml) | Control | 10 | 4.50 | 22.29 | 12.59 ± 6.07 | 100.00 | 0.019 | |
VPA | 10 | 3.61 | 24.96 | 15.47 ± 7.56 | 122.86 | 0.360 | ||
VPA-CUR | 10 | 4.50 | 11.61 | 7.96 ± 2.22 | 63.25 | 0.044 | ||
CUR | 10 | 3.61 | 16.95 | 9.87 ± 3.86 | 78.36 | 0.246 | ||
IFN-γ (pg\ml) | Control | 10 | 206.47 | 407.59 | 331.64 ± 87.78 | 100.00 | 0.038 | |
VPA | 10 | 152.14 | 343.25 | 249.08 ± 58.88 | 75.10 | 0.024 | ||
VPA-CUR | 10 | 167.86 | 366.84 | 244.41 ± 69.94c | 73.70 | 0.024 | ||
CUR | 10 | 117.82 | 359.21 | 237.26 ± 95.02c | 71.54 | 0.033 | ||
CYP450 (ng\ml) | Control | 10 | 33.02 | 40.16 | 36.46 ± 1.79 | 100.00 | 0.085 | |
VPA | 10 | 33.85 | 42.01 | 39.11 ± 2.64 | 107.27 | 0.017 | ||
VPA-CUR | 10 | 34.62 | 43.83 | 37.50 ± 2.82 | 102.87 | 0.335 | ||
CUR | 10 | 34.14 | 43.83 | 38.96 ± 2.92 | 106.85 | 0.033 | ||
5HT (ng\ml) | Control | 10 | 113.92 | 169.46 | 148.75 ± 15.22 | 100.00 | 0.228 | |
VPA | 10 | 109.57 | 174.05 | 140.14 ± 22.04 | 94.22 | 0.323 | ||
VPA-CUR | 10 | 85.18 | 181.05 | 135.77 ± 32.81 | 91.28 | 0.278 | ||
CUR | 10 | 122.13 | 215.83 | 158.84 ± 30.84 | 106.78 | 0.366 | ||
Glutamine (pmol\ml) | Control | 10 | 1640.31 | 2540.39 | 2186.87 ± 302.70 | 100.00 | 0.001 | |
VPA | 10 | 1861.71 | 2549.07 | 2082.25 ± 216.82 | 95.22 | 0.386 | ||
VPA-CUR | 10 | 1456.53 | 2052.73 | 1763.15 ± 165.27c | 80.62 | 0.002 | ||
CUR | 10 | 1388.51 | 2324.78 | 1798.91 ± 274.83c | 82.26 | 0.008 | ||
Glutamate (nmol\ml) | Control | 10 | 215.20 | 286.01 | 249.53 ± 24.68 | 100.00 | 0.002 | |
VPA | 10 | 235.78 | 283.18 | 258.51 ± 14.04 | 103.60 | 0.334 | ||
VPA-CUR | 10 | 178.70 | 283.58 | 232.05 ± 34.97 | 92.99 | 0.213 | ||
CUR | 10 | 168.81 | 272.09 | 206.71 ± 39.12c | 82.84 | 0.009 | ||
Glutamate/Glutamine Ratio | Control | 10 | 0.10 | 0.16 | 0.116 ± 0.018 | 100.00 | 0.063 | |
VPA | 10 | 0.11 | 0.14 | 0.125 ± 0.011 | 108.04 | 0.169 | ||
VPA-CUR | 10 | 0.10 | 0.16 | 0.132 ± 0.017 | 113.83 | 0.051 | ||
CUR | 10 | 0.10 | 0.14 | 0.115 ± 0.016 | 99.65 | 0.963 |