Skip to main content

Table 2 Mean ± S.D. together with the independent t-test for Interleukin-6, Interferon Gamma, cytochrome P450, Serotonin, Glutamine, Glutamate together with Glutamate/Glutamine Ratio in neuro-intoxicated, protected and therapeutically treated rat pups compared to healthy control

From: Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

Parameter Group N Min Max Mean ± S.D. Percent Change P valuea P valueb
IL-6 (pg\ml) Control 10 4.50 22.29 12.59 ± 6.07 100.00   0.019
VPA 10 3.61 24.96 15.47 ± 7.56 122.86 0.360
VPA-CUR 10 4.50 11.61 7.96 ± 2.22 63.25 0.044
CUR 10 3.61 16.95 9.87 ± 3.86 78.36 0.246
IFN-γ (pg\ml) Control 10 206.47 407.59 331.64 ± 87.78 100.00   0.038
VPA 10 152.14 343.25 249.08 ± 58.88 75.10 0.024
VPA-CUR 10 167.86 366.84 244.41 ± 69.94c 73.70 0.024
CUR 10 117.82 359.21 237.26 ± 95.02c 71.54 0.033
CYP450 (ng\ml) Control 10 33.02 40.16 36.46 ± 1.79 100.00   0.085
VPA 10 33.85 42.01 39.11 ± 2.64 107.27 0.017
VPA-CUR 10 34.62 43.83 37.50 ± 2.82 102.87 0.335
CUR 10 34.14 43.83 38.96 ± 2.92 106.85 0.033
5HT (ng\ml) Control 10 113.92 169.46 148.75 ± 15.22 100.00   0.228
VPA 10 109.57 174.05 140.14 ± 22.04 94.22 0.323
VPA-CUR 10 85.18 181.05 135.77 ± 32.81 91.28 0.278
CUR 10 122.13 215.83 158.84 ± 30.84 106.78 0.366
Glutamine (pmol\ml) Control 10 1640.31 2540.39 2186.87 ± 302.70 100.00   0.001
VPA 10 1861.71 2549.07 2082.25 ± 216.82 95.22 0.386
VPA-CUR 10 1456.53 2052.73 1763.15 ± 165.27c 80.62 0.002
CUR 10 1388.51 2324.78 1798.91 ± 274.83c 82.26 0.008
Glutamate (nmol\ml) Control 10 215.20 286.01 249.53 ± 24.68 100.00   0.002
VPA 10 235.78 283.18 258.51 ± 14.04 103.60 0.334
VPA-CUR 10 178.70 283.58 232.05 ± 34.97 92.99 0.213
CUR 10 168.81 272.09 206.71 ± 39.12c 82.84 0.009
Glutamate/Glutamine Ratio Control 10 0.10 0.16 0.116 ± 0.018 100.00   0.063
VPA 10 0.11 0.14 0.125 ± 0.011 108.04 0.169
VPA-CUR 10 0.10 0.16 0.132 ± 0.017 113.83 0.051
CUR 10 0.10 0.14 0.115 ± 0.016 99.65 0.963
  1. a P value between control group and other groups
  2. b P value between all groups
  3. cIndicates there is significant difference between the group and control at 0.05 level