Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content

Table 2 Inhibitory effect of crude ethanol extract (CEE) and BuOH fraction (BuOH fr.) from S. orientalis on serum uric acid levels in rats

Group treatment	Number	Dose (mg/kg)	Serum uric acid levels (μmol/L)	Inhibition (%)
Normal	8		114.54 ± 11.23
Control	8		222.38 ± 24.58^##
CEE	8	600	163.58 ± 12.94*	26.4
BuOH fr.	8	120	152.47 ± 11.68**	31.4
Allopurinol	8	10	115.28 ± 11.13**	48.2

Hyperuricemic rats were induced by a potassium oxonate injection 1 h before the last drug administration. The CEE at 600 mg/kg, the BuOH fr. at 120 mg and allopurinol at 10 mg/kg were orally administrated once a day for five consecutive days. The control and normal groups were orally administered with 0.5% CMC-Na. The serum uric acid levels of rats were measured by the phosphotungstic acid method. Values are displayed as mean ± SEM
*p < 0.05, **p< 0.01 vs. hyperuricemic rats (control);
#p < 0.05, ##p < 0.01 vs. normal rats

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