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Table 2 Inhibitory effect of crude ethanol extract (CEE) and BuOH fraction (BuOH fr.) from S. orientalis on serum uric acid levels in rats

From: Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content

Group treatment Number Dose (mg/kg) Serum uric acid levels (μmol/L) Inhibition (%)
Normal 8   114.54 ± 11.23  
Control 8   222.38 ± 24.58##  
CEE 8 600 163.58 ± 12.94* 26.4
BuOH fr. 8 120 152.47 ± 11.68** 31.4
Allopurinol 8 10 115.28 ± 11.13** 48.2
  1. Hyperuricemic rats were induced by a potassium oxonate injection 1 h before the last drug administration. The CEE at 600 mg/kg, the BuOH fr. at 120 mg and allopurinol at 10 mg/kg were orally administrated once a day for five consecutive days. The control and normal groups were orally administered with 0.5% CMC-Na. The serum uric acid levels of rats were measured by the phosphotungstic acid method. Values are displayed as mean ± SEM
  2. *p < 0.05, **p< 0.01 vs. hyperuricemic rats (control);
  3. #p < 0.05, ##p < 0.01 vs. normal rats