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Table 1 Inhibitory effect of crude ethanol extract (CEE) from S. orientalis on serum uric acid levels in rats

From: Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content

Group treatment Dose (mg/kg) Number Serum uric acid levels (μmol/L) Inhibition (%)
Normal    116.17 ± 8.71  
Control   8 218.66 ± 16.82##  
CEE 300 8 174.49 ± 12.31 20.2
  600 8 159.16 ± 16.36* 27.2
  1200 8 158.18 ± 14.07* 27.7
Allopurinol 10 8 101.69 ± 15.98** 53.5
  1. Hyperuricemic rats were induced by a potassium oxonate injection 1 h before the last drug administration. The CEE at 300, 600 and 1200 mg/kg and allopurinol at 10 mg/kg were orally administrated once a day for five consecutive days. The control and normal groups were orally administered with 0.5% CMC-Na. The serum uric acid levels of rats were measured by the phosphotungstic acid method. Values are displayed as mean ± SEM
  2. *p < 0.05, **p < 0.01 vs. hyperuricemic rats (control);
  3. #p < 0.05, ##p < 0.01 vs. normal rats