Fig. 7From: Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regenerationSchematic model of the survival and proliferative effects of AOF extract on RSC96 Schwann cell. Stimulation of Schwann cell with AOF extract activate IGF-I signaling, leading to upregulation of the PI3K/Akt pathway and activation of the cell cycle regulatory proteins cyclin D1, E and A, resulting in the survival and proliferation of RSC96 Schwann cellBack to article page