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Table 2 Antidepressant like effect of A. hydaspica in acute and repeated doses in FST and TST (Immobility behavior) models

From: Anti-depressant and anxiolytic potential of Acacia hydaspica R. Parker aerial parts extract: Modulation of brain antioxidant enzyme status

Treatment

FST

(Immobility time in seconds)

TST

(Immobility time in seconds)

Acute dose study

 Control

171.0±3.79

192.3±2.85

 AHM

33.33±2.85***

37±2.52***

 AHH

168.0±3.51b

181.3±1.86

 AHE

32.0±2.52***

35.67±2.73***

 AHC

166.7±2.33b

183.3±1.45

 AHB

156.0±3.79*

179.3±2.33*

 AHA

172.0±2.52

182.0±3.60

 Fluoxetine

30.33±2.03***

34.67±2.91***

1 week dose study

 Control (CMS)

189.0±2.79

204.3±3.01

 AHM

35.36±2.55***

38.2±2.32***

 AHE

34.51±3.01***

35.67±2.63***

 Fluoxetine

33.13±2.63***

36.77±2.98***

  1. Data presented as mean±SEM (n=6). Asterisks *, *** indicate significant (p<0.05 and p<0.0001 respectively) difference from respective control groups in both experiments. Data analyzed by one way ANOVA followed by Tukey’s multiple comparison tests