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Table 5 MGIT-DST of MDR-Mtb with Exo-MS alone and in combination with INH and RIF

From: Preliminary evaluation of anti-tuberculosis potential of siderophores against drug-resistant Mycobacterium tuberculosis by mycobacteria growth indicator tube-drug sensitivity test

MDR- Mtb (INH R + RIF R) Isolate Exo-MS (mg/mL) Exo-MS (mg/mL) + INH 0.1 μg/mL Exo-MS (mg/mL) + RIF 1.0 μg/mL Ferric citrate + Exo-MS (mg/mL)
0.125 0.25 0.5 0.125 0.25 0.5 0.125 0.25 0.5 0.5
1 400 400 400 400 400 400 400 400 400 400
2 400 400 0 400 400 0 400 400 0 400
3 400 400 0 400 400 0 400 400 12 400
4 400 400 400 400 400 400 400 400 400 400
5 400 400 253 400 400 105 400 400 131 400
INFERENCE R R S n = 2 R R S n = 2 R R S n = 2 R
  1. GU value of GC for all five isolates was 400. GU value in INH- and RIF-containing medium for all isolates was also 400. R resistant, S Susceptible. If the GU value of the drug-containing tube is ≥100, the interpretation is Resistant by the MGIT instrument. If the GU value of the drug tube is <100, the interpretation is Susceptible (n = no. of isolates susceptible)
  2. Inhibitory effect of Exo-MS, Exo-MS + INH, Exo-MS + RIF on five clinical isolates of MDR-Mtb (INH-, RIF- and PZA-resistant). The medium used was Middlebrook 7H9 broth, pH = 7 incubated at 37 °C for14 days in the MGIT instrument