Pharmacological basis for the medicinal use of polyherbal formulation and its ingredients in cardiovascular disorders using rodents

Table 6 EC₅₀ values of the test materials against force and rate of contractions in guinea-pig atria

Test materials	Force (inhibition) with resultant EC₅₀ values with 95% confidence interval/Mean ± SEM, n = 3–7	Rate (inhibition) with resultant EC₅₀values, n = 3–7
POL_4.Cr	1.28 mg/ml (1.08–1.52)	1.22 mg/ml (0.70–2.15)
Verapamil	0.14 mg/ml (0.11–0.83)	0.19 mg/ml (0.15–0.24)
Ci.Cr	4.18 mg/ml (3.92–4.46)	3.16 mg/ml (2.95–3.39)
Gs.Cr	2.47 mg/ml (2.24–2.72)	3.16 mg/ml (3.03–3.30)
Ns.Cr	Mild cardiac stimulation (110.66 ± 2.33%) at 0.03 mg/ml followed by inhibition at 1–10 mg/ml.	2.47 mg/ml (2.06–2.95)
Tfg.Cr	3.65 mg/ml (3.21–4.16)	3.516 mg/ml (3.23–3.82)

Abbreviations: POL ₄ .Cr the crude extract of poly herbal formulation, Ci.Cr the crude extract of C. intybus, Gs.Cr the crude extract of G. sylvestre, Ns.Cr the crude extract of N. sativa, Tfg.Cr the crude extract of T. foenum graecum

ISSN: 2662-7671