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Table 6 EC50 values of the test materials against force and rate of contractions in guinea-pig atria

From: Pharmacological basis for the medicinal use of polyherbal formulation and its ingredients in cardiovascular disorders using rodents

Test materials Force (inhibition) with resultant EC50 values with 95% confidence interval/Mean ± SEM, n = 3–7 Rate (inhibition) with resultant EC50values, n = 3–7
POL4.Cr 1.28 mg/ml (1.08–1.52) 1.22 mg/ml (0.70–2.15)
Verapamil 0.14 mg/ml (0.11–0.83) 0.19 mg/ml (0.15–0.24)
Ci.Cr 4.18 mg/ml (3.92–4.46) 3.16 mg/ml (2.95–3.39)
Gs.Cr 2.47 mg/ml (2.24–2.72) 3.16 mg/ml (3.03–3.30)
Ns.Cr Mild cardiac stimulation (110.66 ± 2.33%) at 0.03 mg/ml followed by inhibition at 1–10 mg/ml. 2.47 mg/ml (2.06–2.95)
Tfg.Cr 3.65 mg/ml (3.21–4.16) 3.516 mg/ml (3.23–3.82)
  1. Abbreviations: POL 4 .Cr the crude extract of poly herbal formulation, Ci.Cr the crude extract of C. intybus, Gs.Cr the crude extract of G. sylvestre, Ns.Cr the crude extract of N. sativa, Tfg.Cr the crude extract of T. foenum graecum