Pharmacological basis for the medicinal use of polyherbal formulation and its ingredients in cardiovascular disorders using rodents

Table 5 Percentage maximal response of Ca⁺⁺ (% E_max) without and with test materials in rat aortic tissues

Test materials	Concentration	% E_max of Ca⁺⁺ ± SEM, n = 4–7	P value
Control	-	100 ± 0	-
POL₄.Cr (mg/ml)	1	52.66 ± 8.62	p < 0.001
	3	25.66 ± 3.18	p < 0.001
Verapamil (μM)	0.03	63.85 ± 4.00	p < 0.001
	0.1	18.65 ± 4.09	p < 0.001
Ci.Cr (mg/ml)	0.1	62.33 ± 3.84	p < 0.001
	0.3	49.00 ± 4.00	p < 0.001
Gs.Cr (mg/ml)	3	68.33 ± 4.41	p < 0.001
	5	17.93 ± 5.50	p < 0.001
Ns.Cr (mg/ml)	0.03	73.00 ± 3.39	p < 0.001
	0.1	37.00 ± 2.38	p < 0.001
Tfg.Cr (mg/ml)	0.3	62.33 ± 4.33	p < 0.001
	1	33.33 ± 7.26	p < 0.001

p-value were obtained by comparing the concentration–response curves of Ca⁺⁺ in the absence (control) and presence of respective test material(s) using two-way analysis of variance (ANOVA) followed by Bonferroni’s post-test correction
Abbreviations: POL ₄ .Cr the crude extract of poly herbal formulation, Ci.Cr the crude extract of C. intybus, Gs.Cr the crude extract of G. sylvestre, Ns.Cr the crude extract of N. sativa, Tfg.Cr the crude extract of T. foenum graecum

ISSN: 2662-7671