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Table 2 Neuropeptides and CRP in healthy individuals

From: Effects of mindfulness-based interventions on biomarkers in healthy and cancer populations: a systematic review

Reference Participants Study design Interventions Controls Follow up Outcomes Findings
Oken et al. (2010) [21] 31 Dementia caregivers RCT (pilot) MM (N = 10)
6 weeks + common first-week session
Education (N = 11)
6 weeks + common first-week session
Respite (N = 10)
7 weeks respite care
No IL-6, TNF-α, HS-CRP, salivary cortisol There were no pre- and post-intervention differences in the levels of HS-CRP between the different intervention conditions (p > 0.05).
Creswell et al. (2012) [35] 40 ≥ 55y RCT (small) MBSR (N = 20)
8 weeks
Wait-list Control
(N = 20)
No IL-6, CRP, pro-inflammatory gene expression Compared to the control group, a decrease in log-transformed CRP between pre- and post-intervention (p = 0.08).
Gallegos et al. (2013) [36] 200 ≥ 65y RCT MBSR (N = 100)
8 weeks
Wait-list Control
(N = 100)
24 weeks IL-6, IGF-1, IgM and IgG antibody response There were positive effects of MBSR activities between IGF-1 levels and yoga, and sitting meditation (p < 0.01).
Johnson et al. (2014) [22] 281 Marine infantries NRCT MT (N = 147)
8 weeks
Usual training
(N = 134)
No plasma neuropeptide Y (NPY), norepinephrine There were no significant pre- and post-intervention differences in plasma concentrations of NPY between MT intervention and the control group.
The MT intervention group had lower plasma concentrations of NPY than the control group after the stressful training (p < 0.01).
  1. Abbreviations: HS-CRP high-sensitivity C-reactive protein, IGF-1, insulin-like growth factor 1, IgG immunoglobulin G, IgM immunoglobulin M, IL interleukin, MBSR mindfulness-based stress reduction, MM Mindfulness meditation intervention, MT Mindfulness Training, Open open trial with a pre-post trial, RCT randomized controlled trial, NRCT non-randomized controlled trial, TNF-α tumour necrosis factor alpha