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Table 1 Liver function and lipid profiling

From: UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss

Group

Dose (mg/kg)

ALT (U/L)

AST (U/L)

Glucose (mg/dL)

T-chol (mg/dL)

TG (mg/dL)

LDL-C (mg/dL)

HDL-C (mg/dL)

NC

0

21.6 ± 1.7

45.3 ± 13.8

206.4 ± 46.6*

101.1 ± 17.4‡

14.1 ± 3.4†

2.8 ± 0.8‡

57.6 ± 10.4*

HFF

0

36.2 ± 21.3

58.2 ± 10.0

280.6 ± 54.6

169.4 ± 17.2

32.7 ± 11.3

8.9 ± 2.4

69.5 ± 3.4

ORI

40

17.0 ± 2.2*

45.8 ± 4.2*

238.6 ± 69.0

139.1 ± 18.0†

51.3 ± 27.1

5.0 ± 1.2†

68.6 ± 6.2

UP601

300

19.5 ± 4.8

47.7 ± 4.2*

271.3 ± 35.4

153.9 ± 9.5

18.0 ± 9.4*

5.8 ± 0.5†

65.2 ± 3.7*

UP601

450

19.8 ± 12.2

53.1 ± 19.6

219.9 ± 35.1*

140.7 ± 16.5†

14.7 ± 6.1†

5.6 ± 0.9†

65.1 ± 4.1

UP601

600

16.5 ± 7.5*

48.7 ± 19.1

186.1 ± 47.1†

118.9 ± 21.0‡

11.9 ± 4.8†

5.2 ± 1.2†

57.7 ± 10.5*

  1. HFF-induced obese C57BL/6J mice were treated with UP601 at oral doses of 300, 450 and 600 mg/kg for 7-weeks. Orlistat (ORI) at 40 mg/kg was used as a reference compound. Serum samples were collected at necropsy. ALT alanine aminotransferase, AST aspartate aminotransferase, T-chol total cholesterol, TG triglycerides, LDL C low-density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol. NC Normal control + vehicle, HFF HFF + Vehicle, ORI HFF + orlistat, UP601 HFF + indicated concentrations of UP601. *P ≤ 0.05 compared to HFF group;P ≤ 0.001 compared to HFF group;P ≤ 0.0001 compared to HFF group