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Table 1 Liver function and lipid profiling

From: UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss

Group Dose (mg/kg) ALT (U/L) AST (U/L) Glucose (mg/dL) T-chol (mg/dL) TG (mg/dL) LDL-C (mg/dL) HDL-C (mg/dL)
NC 0 21.6 ± 1.7 45.3 ± 13.8 206.4 ± 46.6* 101.1 ± 17.4‡ 14.1 ± 3.4† 2.8 ± 0.8‡ 57.6 ± 10.4*
HFF 0 36.2 ± 21.3 58.2 ± 10.0 280.6 ± 54.6 169.4 ± 17.2 32.7 ± 11.3 8.9 ± 2.4 69.5 ± 3.4
ORI 40 17.0 ± 2.2* 45.8 ± 4.2* 238.6 ± 69.0 139.1 ± 18.0† 51.3 ± 27.1 5.0 ± 1.2† 68.6 ± 6.2
UP601 300 19.5 ± 4.8 47.7 ± 4.2* 271.3 ± 35.4 153.9 ± 9.5 18.0 ± 9.4* 5.8 ± 0.5† 65.2 ± 3.7*
UP601 450 19.8 ± 12.2 53.1 ± 19.6 219.9 ± 35.1* 140.7 ± 16.5† 14.7 ± 6.1† 5.6 ± 0.9† 65.1 ± 4.1
UP601 600 16.5 ± 7.5* 48.7 ± 19.1 186.1 ± 47.1† 118.9 ± 21.0‡ 11.9 ± 4.8† 5.2 ± 1.2† 57.7 ± 10.5*
  1. HFF-induced obese C57BL/6J mice were treated with UP601 at oral doses of 300, 450 and 600 mg/kg for 7-weeks. Orlistat (ORI) at 40 mg/kg was used as a reference compound. Serum samples were collected at necropsy. ALT alanine aminotransferase, AST aspartate aminotransferase, T-chol total cholesterol, TG triglycerides, LDL C low-density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol. NC Normal control + vehicle, HFF HFF + Vehicle, ORI HFF + orlistat, UP601 HFF + indicated concentrations of UP601. *P ≤ 0.05 compared to HFF group;P ≤ 0.001 compared to HFF group;P ≤ 0.0001 compared to HFF group