Fig. 2

Body weight changes observed after 7 weeks of daily oral UP601 treatment in HFF fed obese C57BL/6J mice. HFF-induced obese C57BL/6J mice were treated with UP601 at oral doses of 300, 450 and 600 mg/kg for 7-weeks. Orlistat (ORI) at 40 mg/kg was used as a reference compound. N = 7 for each group; **P ≤ 0.0001 compared to HFF group; †P ≤ 0.001 compared to HFF group; *P ≤ 0.05 compared to HFF group