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Table 5 PK parameters of AA II in rats after oral administration of AF and HAF (mean ± SD, n = 6)

From: Comparative studies on the multi-component pharmacokinetics of Aristolochiae Fructus and honey-fried Aristolochiae Fructus extracts after oral administration in rats

Parameter Unit Low-dose Mid-dose High-dose
AF HAF AF HAF AF HAF
Dose mg/kg 0.21 0.26 0.56 0.69 1.05 1.29
C max μg/L 590.5 ± 191.1 293.0 ± 55.2* 1137.1 ± 193.1 411.8 ± 104.2* 1518.0 ± 200.0 528.2 ± 62.4*
Tmax h 1.03 ± 0.18 0.81 ± 0.14 1.33 ± 0.21 0.81 ± 0.16 1.83 ± 0.29 0.93 ± 0.19
t 1/2z h 4.98 ± 0.55 4.94 ± 0.61 5.06 ± 0.49 4.95 ± 0.53 5.16 ± 0.52 5.39 ± 0.48
AUC(0-∞) μg/L · h 3958.9 ± 1002.8 2716.2 ± 795.2* 7824.5 ± 1975.8 3874.5 ± 1201.6* 12709.2 ± 2964.7 5628.0 ± 1693.4*
Vz/F L/kg 0.49 ± 0.06 0.55 ± 0.07 0.48 ± 0.05 0.49 ± 0.06 0.82 ± 0.09 0.72 ± 0.08
CLz/F L/h/kg 0.07 ± 0.02 0.08 ± 0.02 0.07 ± 0.02 0.07 ± 0.02 0.11 ± 0.03 0.09 ± 0.02
  1. *P < 0.05 compared with AF group