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Table 4 PK parameters of AA I in rats after oral administration of AF and HAF (mean ± SD, n = 6)

From: Comparative studies on the multi-component pharmacokinetics of Aristolochiae Fructus and honey-fried Aristolochiae Fructus extracts after oral administration in rats

Parameter Unit Low-dose Mid-dose High-dose
AF HAF AF HAF AF HAF
Dose mg/kg 3.0 3.0 8.0 8.0 15.0 15.0
C max μg/L 1704.0 ± 570.8 1072.3 ± 223.1* 3823.8 ± 450.3 2002.5 ± 312.8* 5891.3 ± 425.5 3474.3 ± 352.3*
Tmax h 0.50 ± 0.09 0.39 ± 0.08 0.56 ± 0.09 0.42 ± 0.08 0.69 ± 0.10 0.47 ± 0.08
t 1/2z h 3.50 ± 0.50 3.22 ± 0.46 5.58 ± 0.65 4.72 ± 0.52 5.46 ± 0.53 5.32 ± 0.54
AUC(0-∞) μg/L · h 6080.4 ± 1263.2 5227.0 ± 895.6* 12770.7 ± 1857.5 8985.3 ± 1784.9* 26844.6 ± 3264.7 11782.2 ± 1769.2*
Vz/F L/kg 2.85 ± 0.15 2.75 ± 0.24 5.40 ± 0.48 4.58 ± 0.37 7.13 ± 0.57 5.53 ± 0.52
CLz/F L/h/kg 0.57 ± 0.06 0.59 ± 0.08 0.65 ± 0.09 0.68 ± 0.07 0.87 ± 0.12 0.72 ± 0.08
  1. *P < 0.05 compared with AF group