Iridoids from Canthium subcordatum iso-butanol fraction with potent biological activities

Table 1 Antibacterial activity (MIC and MBC in μg/ml) of extracts, isolated compounds and reference antibacterial drugs

Extracts/compounds	Inhibition parameters	Vibrio cholerae SG24 (1)	Vibrio cholerae CO6	Vibrio cholerae NB2	Vibrio cholerae PC2	Shigella flexneri SDINT	Staphylococcus aureus ATCC 25923
MeOH extract	MIC	512	256	512	512	256	128
	MBC	512	256	512	512	256	256
	MBC/MIC	1	1	1	1	1	2
n-BuOH extract	MIC	512	512	512	512	256	128
	MBC	>512	512	512	>512	512	128
	MBC/MIC	/	1	1	/	2	1
EtOAc extract	MIC	512	128	256	512	256	128
	MBC	512	256	512	512	512	128
	MBC/MIC	1	2	2	1	2	1
Hexane extract	MIC	>512	512	512	512	256	256
	MBC	/	>512	>512	>512	>512	>512
	MBC/MIC	/	/	/	/	/	/
1	MIC	64	64	64	64	32	32
	MBC	128	64	64	64	64	32
	MBC/MIC	2	1	1	1	2	1
2	MIC	256	128	128	256	128	64
	MBC	>256	256	128	256	256	64
	MBC/MIC	/	2	1	1	2	1
3	MIC	>256	128	256	256	256	256
	MBC	/	256	256	>256	>256	>256
	MBC/MIC	/	2	1	/	/	/
5a	MIC	256	128	128	128	128	128
	MBC	>256	256	128	256	128	128
	MBC/MIC	/	2	1	2	1	1
6	MIC	128	256	256	128	32	32
	MBC	256	256	256	256	64	64
	MBC/MIC	2	1	1	2	2	2
7	MIC	32	64	32	32	16	8
	MBC	64	128	32	32	16	8
	MBC/MIC	2	2	1	1	1	1
8	MIC	256	256	128	128	128	64
	MBC	>256	256	>256	256	256	128
	MBC/MIC	/	1	/	2	2	2
9	MIC	128	128	128	256	128	128
	MBC	128	>256	128	256	256	256
	MBC/MIC	1	/	1	1	2	2
Ampicillin	MIC	16	16	>512	>512	>512	8
	MBC	16	16	>512	>512	>512	8
	MBC/MIC	1	1	/	/	/	1
Ciprofloxacin	MIC	8	8	16	16	16	2
	MBC	8	8	16	16	16	2
	MBC/MIC	1	1	1	1	1	1

/ not determined, MIC minimum inhibitory concentration, MBC minimum bactericidal concentration

ISSN: 2662-7671