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Fig. 2 | BMC Complementary and Alternative Medicine

Fig. 2

From: Effect of ginseng extract on the TGF-β1 signaling pathway in CCl4-induced liver fibrosis in rats

Fig. 2

Light micrographs of liver sections of rat. Specimens were fixed in 10% neutral formalin and stained with Masson Trichrome. a-b Control rat (GI). a Control rat (GI) with poorly defined classical hepatic lobules and central veins (Cv) (magnification 100x). b: A hexagonal hepatocyte with central nucleus (N) and prominent nucleolus (Nu) arranged in strands around the central vein (Cv) and blood sinusoids (Bs) (magnification 400x). c-g Rats treated with CCl4 (GIII). e Hydropic degeneration and vacuolated hepatocytes. (N) Nuclei, (V) vacuoles. A marked increase in collagen fibers (arrows) around a congested central vein (Cv) and degenerated hepatocytes with nuclei (N) (magnification 1000x). f Fatty changes liver (stars) and collapsed sinusoids. f: Collagen fibers (arrows) around collapsed sinusoids. An increase in binucleated hepatocytes (stars) and vacuoles (V) was observed (magnification 1000x). g Fibrosis in the portal area (arrows). (Hv) hepatic portal vein, (Ha) hepatic artery, and (Bd) proliferated bile duct (magnification 400x). h Ginseng supplementation with CCl4 (GIV) reduced the accumulation of collagen fibers after CCl4 administration. (Cv) central veins, (arrows) blood sinusoids (magnification 400x). i Nearly normal hepatic strands and hepatocytes of GIV with nuclei (N) and nucleoli (Nu), and the reduction of perisinusoidal collagen fibers. Bs: blood sinusoids (magnification 1000x)

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