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Fig. 8 | BMC Complementary and Alternative Medicine

Fig. 8

From: Cheongsangbangpung-tang ameliorated the acute inflammatory response via the inhibition of NF-κB activation and MAPK phosphorylation

Fig. 8

The inhibitory effect of CBTE on paw skin thickness and infiltrated inflammatory cells. Changes in histological profiles, paw skin thickness (a) and infiltrated inflammatory cells (b) of the dorsum and ventrum pedis skin in normal a, carrageenan b, dexamethasone c, 0.3 g/kg CBTE d and 1.0 g/kg CBTE e treated groups (c d). After 4 h of carrageenan treatment, the dorsum and ventrum pedis skins were separated and fixed in 10% neutral buffered formalin then embedded in paraffin, sectioned and stained with haematoxylin and eosin. Note that marked increases of dorsum (c) and ventrum (d) pedis skin thicknesses (arrow) due to oedematous changes were detected following carrageenan treatment with increases in inflammatory cell infiltrations compared with the normal skin. However, these increases in skin thicknesses and inflammatory cell infiltrations were effectively inhibited by treatment with dexamethasone and were also dose-dependently affected by treatment with two different dosages of CBTE 0.3 and 1.0 g/kg. Scale bars = 60 μm. CBTE, Cheongsangbangpung-tang extract; CA, carrageenan; DEXA, dexamethasone

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