Fig. 2

Effects of CIE on histopathological changes in the joints of AIA mice (original magnification 200×). a Vehicle control, (b) AIA model, (c) CIE (0.4 g/kg) and (d) CIE (0.8 g/kg). Representative sections from one rat are given for each group. All sections were stained with hematoxylin and eosin. Morphological changes (e) was graded on a scale of 0–4. The data was presented as mean ± S.D. of ten mice per group. *** p < 0.001 compared with the vehicle control group; # p < 0.05 compared with the AIA model group