Table 1 Inhibition parameters (MIC, MBC) of compounds 1–3 and reference antibacterial drugs
Antibacterial activity (MIC and MBC in ÎĽg/mL) | |||||||
|---|---|---|---|---|---|---|---|
Compounds | Inhibition parameters | V. cholerae SG24 | V. cholerae CO6 | V. cholerae NB2 | V. cholerae PC2 | S. flexneri SDINT | S. aureus ATCC 25923 |
1 | MIC | >512 | 512 | 512 | >512 | 128 | 128 |
MBC | >512 | 512 | 512 | >512 | 128 | 128 | |
MBC/MIC | / | 1 | 1 | / | 1 | 1 | |
2 | MIC | >512 | 512 | 512 | 256 | 128 | 256 |
MBC | >512 | 512 | 512 | 256 | 128 | 256 | |
MBC/MIC | / | 1 | 1 | 1 | 1 | 1 | |
3 | MIC | >512 | 512 | 512 | >512 | 128 | 512 |
MBC | >512 | 512 | 512 | >512 | 128 | 512 | |
MBC/MIC | / | 1 | 1 | / | 1 | 1 | |
Tetracycline | MIC | 0.50 | 2 | 0.50 | 0.50 | 16 | 16 |
MBC | 1 | 8 | 2 | 1 | 32 | 32 | |
MBC/MIC | 2 | 4 | 4 | 2 | 2 | 2 | |
Ampicillin | MIC | 16 | 16 | >512 | >512 | >512 | 16 |
MBC | 16 | 16 | >512 | >512 | >512 | 16 | |
MBC/MIC | 1 | 1 | / | / | / | 1 | |