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Table 4 Effects of the aqueous extract of V. heterophylla on index kidney function

From: Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats

Drugs (mg/kg) Control 150 mg/kg 200 mg/kg 250 mg/kg Furosemide (5 mg/kg) HCTZ (10 mg/kg)
Creatinine (mg/24 h) 26,66 ± 1,76 17,77 ± 1,14*** 23,45 ± 1,22** 27,54 ± 1,34* 22,33 ± 1,32** 28,67 ± 1,43
CreatC (mL/min) 0,027 ± 0,33 0,025 ± 0,14* 0,023 ± 0,24** 0,021 ± 0,11*** 0,022 ± 0,31** 0,020 ± 0,22***
Urea (g/24 h) 26,15 ± 1,16 22,25 ± 1,01*** 23,14 ± 1,23* 24,45 ± 1,66 24,76 ± 1,42** 22,68 ± 0,34***
Uosm (mosmol/kg) 198,45 ± 8,73 109,11 ± 12,98*** 112,31 ± 13,46*** 125,43 ± 11,24*** 169,56 ± 12,21*** 166,62 ± 8,11***
GFR (mL/min) 1,74 ± 0,12 1,65 ± 0,33* 1,62 ± 0,11* 1,56 ± 0,16** 1,49 ± 0,22*** 1,46 ± 0,32***
Cosm (mL/min) 0,046 ± 0,013 0,044 ± 0,021 0,047 ± 0,032 0,049 ± 0,043** 0,078 ± 0,046*** 0,067 ± 0,044***
CH20. (mL/min) 0,056 ± 0,012 0,054 ± 0,013 0,056 ± 0,011 0,066 ± 0,016*** 0,068 ± 0,015*** 0,066 ± 0,018***
  1. Values are means ± S.E.M., n = 5, * < 0,05, ** < 0,01, *** < 0,001, significant difference compared to the control
  2. CreatC creatinine clearance, Uosm urinary osmolarity, GFR glomerular filtration rate, Cosm Osmolar clearance, CH 2 0 free water clearance