Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats

Table 4 Effects of the aqueous extract of V. heterophylla on index kidney function

Drugs (mg/kg)	Control	150 mg/kg	200 mg/kg	250 mg/kg	Furosemide (5 mg/kg)	HCTZ (10 mg/kg)
Creatinine (mg/24 h)	26,66 ± 1,76	17,77 ± 1,14***	23,45 ± 1,22**	27,54 ± 1,34*	22,33 ± 1,32**	28,67 ± 1,43
CreatC (mL/min)	0,027 ± 0,33	0,025 ± 0,14*	0,023 ± 0,24**	0,021 ± 0,11***	0,022 ± 0,31**	0,020 ± 0,22***
Urea (g/24 h)	26,15 ± 1,16	22,25 ± 1,01***	23,14 ± 1,23*	24,45 ± 1,66	24,76 ± 1,42**	22,68 ± 0,34***
Uosm (mosmol/kg)	198,45 ± 8,73	109,11 ± 12,98***	112,31 ± 13,46***	125,43 ± 11,24***	169,56 ± 12,21***	166,62 ± 8,11***
GFR (mL/min)	1,74 ± 0,12	1,65 ± 0,33*	1,62 ± 0,11*	1,56 ± 0,16**	1,49 ± 0,22***	1,46 ± 0,32***
Cosm (mL/min)	0,046 ± 0,013	0,044 ± 0,021	0,047 ± 0,032	0,049 ± 0,043**	0,078 ± 0,046***	0,067 ± 0,044***
CH20. (mL/min)	0,056 ± 0,012	0,054 ± 0,013	0,056 ± 0,011	0,066 ± 0,016***	0,068 ± 0,015***	0,066 ± 0,018***

Values are means ± S.E.M., n = 5, * < 0,05, ** < 0,01, *** < 0,001, significant difference compared to the control
CreatC creatinine clearance, Uosm urinary osmolarity, GFR glomerular filtration rate, Cosm Osmolar clearance, CH₂0 free water clearance

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