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Table 3 Effects of the aqueous extract of V. heterophylla on saluretic and natriuretic activity from 24 h of urine

From: Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats

Drugs (mg/kg) Saluretic (Na+ + Cl) Natriuretic (Na+/k+) CAI Cl/(Na + K) Saluretic index Natriuretic index CAI index
Control 42.65 ± 2.52 1.00 ± 1.68 0.45 ± 0.55 1.00 1.00 1.00
Extract 150 112.38 ± 3.55*** 1. 34 ± 1.70* 0.47 ± 0.37* 2.63 1.34 1.04
200 219.66 ± 2.74*** 1.86 ± 1.09** 0.48 ± 0.51** 5.15 1.86 1.06
250 324.95 ± 2.64*** 3.17 ± 0.57*** 0.48 ± 0.53** 7.61 3.17 1.06
Furosémide (5 mg/kg) 201.43 ± 4.33*** 2.49 ± 0.95*** 0.49 ± 0.51** 4.72 2.49 1.08
Amiloride H. (10 mg/kg) 158.99 ± 3.42*** 2.75 ± 1.15*** 0.48 ± 0.61** 3.72 2.75 1.06
  1. Values are means ± S.E.M., n = 5, * < 0.05, ** < 0.01, *** < 0.001, significant difference compared to the control
  2. CAI, carbonic anhydrase inhibition
  3. saluretic index: saluretic activity in test group/saluretic activity in control group
  4. natriuretic index: natriuretic activity in test group/natriuretic activity in control group
  5. carbonic anhydrase inhibition index, CAI activity in test group/CAI activity in control group