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Table 1 Effect of the fractions of Croton macrostachyus leaves on castor oil induced diarrheal model in mice

From: Evaluation of the anti-diarrheal activity of the leaf extract of Croton macrostachyus Hocsht. ex Del. (Euphorbiaceae) in mice model

Group Onset time of diarrhea (min) Total # of wet feces in 4 h Total # of feces Total weight of feces(gm) % inhibition of defecation
Control 76 ± 16.71 4.5 ± 0.72 4.67 ± 0.80 0.82 ± 0.19 ----
Loperamide 3 mg/kg 167.83 ± 25.62a* 0.833 ± 0.31a*** 1.83 ± 0.65a* 0.17 ± 0.044a* 81.49
CF300mg/kg 169.83 ± 22.78a* 1.33 ± 0.42a*** 1.83 ± 0.65a* 0.29 ± 0.14a* 70.37
CF400mg/kg 217.50 ± 22.50a*** 0.33 ± 0.33a*** 0.83 ± 0.31a** 0.14 ± 0.13a* 92.59
CF500mg/kg 238.33 ± 1.67a*** 0.17 ± 0.17a*** 0.167 ± 0.166a*** 0.10 ± 0.10a* 96.296
Control 82.5 ± 19.96 4.67 ± 0.49 5.33 ± 0.42 0.83 ± 0.22 ----
Loperamide 3 mg/kg 167.83 ± 25.62a* 0.833 ± 0.31a*** 1.83 ± 0.65a* 0.17 ± 0.044a* 82.16
MF300mg/kg 143.5 ± 25.54 2.5 ± 0.56 3.83 ± 0.48 0.37 ± 0.15 46.47
MF400mg/kg 186.33 ± 22.19a* 1.17 ± 0.48a** 2.50 ± 0.85a* 0.114 ± 0.05a* 74.95
MF500mg/kg 191.33 ± 30.62a* 0.83 ± 0.48a*** 1.17 ± 0.60a* 0.11 ± 0.06a* 82.23
Control 42.50 ± 4.16 7.00 ± 0.89 6.67 ± 0.80 0.72 ± 0.13 --------
Loperamide 3 mg/kg 120.50 ± 28.07a* 1.50 ± 0.22a**c**d**e*f* 2.00 ± 0.37a*c*d*e* 0.15 ± 0.07a*c**d**e** 78.57
AF300mg/kg 54.17 ± 8.60h**I** 6.83 ± 0.83b**g***h***I*** 8.17 ± 1.66b**g***h***I*** 0.71 ± 0.096b**g***h***I*** 2.43
AF400mg/kg 55.00 ± 8.79 h**I** 6.67 ± 1.05b**g***h***I*** 7.33 ± 0.99b*g***h***I*** 0.69 ± 0.21b**g***h***I*** 4.71
AF500mg/kg 60.67 ± 2.58 h**I** 6.50 ± 1.09b*g***h***I*** 7.17 ± 1.11b*g***h***I*** 0.68 ± 0.06b**g***h***I*** 7.14
AF1000mg/kg 82.17 ± 28.13 h**I** 6.17 ± 1.30b*g***h***I*** 6.33 ± 1.17b*g***h***I*** 0.56 ± 0.11 11.86
  1. Values are expressed as Mean ± S.E.M (n = 6), analysis was performed with One-Way ANOVA followed by Tukey test,a compared to control,b to standard drug,c to 300 mg/kg,d to 400 mg/kg,e to 500 mg/kg,f to 1000 mg/kg,g to CF300mg/kg,h to CF400mg/kg andI to CF500mg/kg; *P <0.05, **P <0.01, ***P <0.001; CF chloroform fraction, MF methanol fraction, AF aqueous fraction. Negative controls were treated with the vehicle used for reconstitution (2 % v/v Tween 80 for the chloroform and methanol fractions or distilled water for the aqueous fraction) orally