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Table 2 Inhibitory effect of the isolated compounds from Zea mays L. on protein tyrosine phosphatase 1β

From: Optimization of extraction parameters of PTP1β (protein tyrosine phosphatase 1β), inhibitory polyphenols, and anthocyanins from Zea mays L. using response surface methodology (RSM)

Compounds Concentration (μg/mL) Inhibition (%) IC50b (μg/ml) IC50 (μM)
Suramina 5 64.32   2.76
2.5 46.46 3.94
1 10.69  
Protochtechuic acid (1) 100 <50.0 - -
Vanillic acid (2) 100 <50.0 - -
2,4,6-Trihydroxybenzoic acid (3) 100 < 50.0 - -
p-Hydroxycinnamic acid (4) 100 < 50.0 - -
Ferulic acid (5) 100 96.09   185.41
50 64.53 35.97
10 28.33  
Hirsutrin (6) 100 < 50.0 - -
3′-Methoxyhirsutrin (7) 50 85.89   64.04
25 36.84 30.61
10 15.02  
Cyanidin-3-glucoside (8) 100 < 50.0 - -
Pelargonidin-3-glucoside (9) 100 55.05   210.81
50 13.35 91.36
10 1.09  
Peonidin-3-glucoside (10) 100 < 50.0 - -
Cyanidin-3-(6”-malonylglucoside) (11) 50 91.73   54.06
25 36.24 28.95
10 18.54  
Peonidin-3-(6”-malonylglucoside) (12) 100 < 50.0 - -
  1. aSuramin was used as positive control
  2. bThe IC50 value was defined as the half-maximal inhibitory concentration and mean of 3 duplication analyses of each sample