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Table 2 Inhibitory effect of the isolated compounds from Zea mays L. on protein tyrosine phosphatase 1β

From: Optimization of extraction parameters of PTP1β (protein tyrosine phosphatase 1β), inhibitory polyphenols, and anthocyanins from Zea mays L. using response surface methodology (RSM)

Compounds

Concentration (μg/mL)

Inhibition (%)

IC50b (μg/ml)

IC50 (μM)

Suramina

5

64.32

 

2.76

2.5

46.46

3.94

1

10.69

 

Protochtechuic acid (1)

100

<50.0

-

-

Vanillic acid (2)

100

<50.0

-

-

2,4,6-Trihydroxybenzoic acid (3)

100

< 50.0

-

-

p-Hydroxycinnamic acid (4)

100

< 50.0

-

-

Ferulic acid (5)

100

96.09

 

185.41

50

64.53

35.97

10

28.33

 

Hirsutrin (6)

100

< 50.0

-

-

3′-Methoxyhirsutrin (7)

50

85.89

 

64.04

25

36.84

30.61

10

15.02

 

Cyanidin-3-glucoside (8)

100

< 50.0

-

-

Pelargonidin-3-glucoside (9)

100

55.05

 

210.81

50

13.35

91.36

10

1.09

 

Peonidin-3-glucoside (10)

100

< 50.0

-

-

Cyanidin-3-(6”-malonylglucoside) (11)

50

91.73

 

54.06

25

36.24

28.95

10

18.54

 

Peonidin-3-(6”-malonylglucoside) (12)

100

< 50.0

-

-

  1. aSuramin was used as positive control
  2. bThe IC50 value was defined as the half-maximal inhibitory concentration and mean of 3 duplication analyses of each sample