Fig. 2

Cell cycle alterations of MG-63 cells. a Histogram of the cell cycle distribution of MG-63 cells after treatment with the control substance (c) and the eight samples of plant extracts at a concentration of 50 μg/ml for 48 h. G1, S, G2/M and sub-G1 phases are marked with black arrows. Represented were the most prominent samples of 3–5 individual replicates. b Calculation of proliferation after treatment with the vehicle (DMSO, EtOH, MeOH; equates to 100 %) and the plant extracts at a concentration of 50 μg/ml for 48 h. As proliferative phases the sum of S and G2/M phases were calculated in percentages. c As apoptotic fraction the sub G1-peak was measured. (mean ± SD, n = 3–5, ***P < 0.001, **P < 0.01, *P < 0.5, significantly different compared to control, one-way ANOVA)