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Table 1 The effect of KOTMIN13 on AHR

From: KOTMIN13, a Korean herbal medicine alleviates allergic inflammation in vivo and in vitro

Group

Concentration

Methacholine-induced Penh level

  

2.5 mg/kg

5 mg/kg

20 mg/kg

30 mg/kg

40 mg/kg

NC

 

1.56 ± 0.13

1.73 ± 0.03

2.15 ± 0.10

3.28 ± 0.25

3.65 ± 0.30

OVA

 

4.31 ± 0.26##

4.71 ± 0.20##

6.47 ± 0.36##

10.50 ± 1.00###

12.00 ± 0.57###

KOTMIN13

50 mg/kg

3.53 ± 0.13*

3.87 ± 0.25*

4.99 ± 0.42*

6.97 ± 0.37**

7.36 ± 0.88**

 

100 mg/kg

2.99 ± 0.23**

3.38 ± 0.18**

5.01 ± 0.28*

5.96 ± 0.39***

6.98 ± 0.26***

 

200 mg/kg

2.34 ± 0.06***

2.69 ± 0.23***

3.70 ± 0.19***

5.16 ± 0.18***

5.17 ± 0.48***

Montelukast

20 mg/kg

3.03 ± 0.20**

3.43 ± 0.18**

5.34 ± 1.34*

5.92 ± 0.28***

6.49 ± 0.23***

Dexamethasone

1 mg/kg

2.00 ± 0.05***

2.30 ± 0.20***

4.09 ± 0.12**

5.16 ± 0.29***

5.13 ± 0.37***

  1. Data were expressed as the mean ± SEM. ##P <0.01 and ###P <0.001 compared with the negative control (NC); *P <0.05, **P <0.01, and ***P <0.001 compared with the OVA group