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Table 1 The effect of KOTMIN13 on AHR

From: KOTMIN13, a Korean herbal medicine alleviates allergic inflammation in vivo and in vitro

Group Concentration Methacholine-induced Penh level
   2.5 mg/kg 5 mg/kg 20 mg/kg 30 mg/kg 40 mg/kg
NC   1.56 ± 0.13 1.73 ± 0.03 2.15 ± 0.10 3.28 ± 0.25 3.65 ± 0.30
OVA   4.31 ± 0.26## 4.71 ± 0.20## 6.47 ± 0.36## 10.50 ± 1.00### 12.00 ± 0.57###
KOTMIN13 50 mg/kg 3.53 ± 0.13* 3.87 ± 0.25* 4.99 ± 0.42* 6.97 ± 0.37** 7.36 ± 0.88**
  100 mg/kg 2.99 ± 0.23** 3.38 ± 0.18** 5.01 ± 0.28* 5.96 ± 0.39*** 6.98 ± 0.26***
  200 mg/kg 2.34 ± 0.06*** 2.69 ± 0.23*** 3.70 ± 0.19*** 5.16 ± 0.18*** 5.17 ± 0.48***
Montelukast 20 mg/kg 3.03 ± 0.20** 3.43 ± 0.18** 5.34 ± 1.34* 5.92 ± 0.28*** 6.49 ± 0.23***
Dexamethasone 1 mg/kg 2.00 ± 0.05*** 2.30 ± 0.20*** 4.09 ± 0.12** 5.16 ± 0.29*** 5.13 ± 0.37***
  1. Data were expressed as the mean ± SEM. ##P <0.01 and ###P <0.001 compared with the negative control (NC); *P <0.05, **P <0.01, and ***P <0.001 compared with the OVA group
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