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Table 4 Antimalarial activities of aqueous, methanol and chloroform extracts of seeds of B. antidysenterica and mean survival time of P. berghie infected mice

From: Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

Extraction solvents B. antidysenterica Extract antimalarial activity on D4 post-infection Mean survival time (days)
  Dose (mg/kg) % Parasitaemia ± SEM % suppression
dH2O 200 39.69 ± 1.10 24.05 9.25 ± 0.69*
400 32.19 ± 0.62 38.40 10 ± 00.54*
600 28.39 ± 1.68 45.68 12.50 ± 0.41*
CH3OH 200 34.36 ± 0.86 38.08 12.90 ± 1.04
400 28.57 ± 1.31 43.33 14.80 ± 1.20*
600 27.99 ± 0.89 46.44 15.00 ± 1.40*
CHCl3 200 35.94 ± 0.86 31.23 12.00 ± 1.70*
400 29.67 ± 1.31 43.23 13.00 ± 0.80*
600 27.33 ± 0.89 47.70 15.50 ± 0.41*
Controls QC (25 mg) 0.00 ± 0.00 100.00 ND
T80 52.26 ± 1.50 0.00 7.00 ± 0.50
  1. Key: Values are presented as M ± SEM; n = 5; T80 = negative control (3 % tween 80); CQ positive control (chloroquine), ND no death within the follow-up interval (30-days), dH 2 O distilled water, CH 3 OH methanol, CHCl 3 chloroform, CQ chloroquine (positive control); * = values are significantly different (p < 0.05) from that of the negative control
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