Fig. 6From: Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathwaysSchematic diagram showing the proposed apoptotic signaling pathways triggered by PP7 in HepG2 cells. PP7 treatment leads to the activation of MAPK (JNK, ERK, and p38) and PTEN/p53 signaling pathways, followed by upregulation of pro-apoptotic proteins and downregulation of anti-apoptotic protein, and eventually causes apoptosis in HepG2 cellsBack to article page