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Table 6 Evaluation of the protective effect of the plants extracts on the biochemical parameters of liver in CCl4-induced hepatic damage in mice

From: Impact of phenolic composition on hepatoprotective and antioxidant effects of four desert medicinal plants

 

Control

CCl4 control

F. indica

Z hamiense

C. procera

S. imbricata

5 mg/kg

10 mg/kg

250 mg/kg

500 mg/kg

100 mg/kg

200 mg/kg

250mg/kg

500mg/kg

ALT (U/L)

290.1 ± 54.0

1736.7 ± 161.2a

2166.7 ± 157.8b

1064.0 ± 264.9c

1416.7 ± 105.8

950.3 ± 84.4

1054.3 ± 117.5c

801.7 ± 76.0c

1135.0 ± 127.9c

476.7 ± 151.0c

AST(U/L)

850.0 ± 63.2

1736.7 ± 215.1a

1310.0 ± 181.5b

926.2 ± 258.6c

756.7 ± 128.6c

783.3 ± 80.1c

787.8 ± 69.6c

922.7 ± 65.4c

647.5 ± 62.8c

530.0 ± 120.8c

ALP(U/L)

180.0 ± 20.3

150.2 ± 55.7

125.0 ± 22.5

124.3 ± 17.4

106.7 ± 24.0

113.3 ± 29.1

51.8 ± 4.7

59.5 ± 6.1 c

110.0 ± 14.7

63.3 ± 8.8

CAT kU/g protein

462.0 ± 21.1

241.3 ± 11.4a

307.2 ± 9.2c

392.200 ± 9.4c

225.1 ± 10.5

259.1 ± 5.1

324.7 ± 25.8b

335.0 ± 25.0c

356.2 ± 24.1c

374.9 ± 10.7c

GSH-Px U/g protein

1.3 ± 0.1

0.85 ± 0.06a

1.1 ± 0.2

1.2 ± 0.2

0.72 ± 0.1

0.94 ± 0.2

1.4 ± 0.06

1.4 ± 0.06

0.91 ± 0.06

1.39 ± 0.19b

SOD μg/g protein

34.6 ± 2.9

22.0 ± 2.4a

26.7 ± 1.8

32.9 ± 1.6c

21.1 ± 1.7

23.6 ± 1.5

22.7 ± 1.2

31.5 ± 1.1b

24.8 ± 0.5

26.4 ± 1.3

TBARS (nmol/g prot.)

0.049 ± 0.02

0.54 ± 0.20a

0.12 ± 0.09c

0.085 ± 0.05c

0.42 ± 0.2

0.36 ± 0.4

0.14 ± 0.07c

0.06 ± 0.01c

0.11 ± 0.05c

0.071 ± 0.02c

  1. aSignificant difference (p < 0.01) compared to control group; bSignificant difference (p < 0.05) compared to CCl4 treated group; cSignificant difference (p < 0.01) compared to CCl4 treated group