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Table 3 Cytotoxic activity of column chromatographic pooled fractions of the hexane extract of P. tetrastromatica, the methanolic extract of C. racemosa and the methanolic extract of T. ornata in the human adenocarcinoma MCF-7 cells and the human non-tumourigenic 184B5 cells

From: Antioxidant and cytotoxic activities of three species of tropical seaweeds

Sample Pooled fractions MCF-7 cells 184B5 cells
IC50 (μg/mL) IC20 (μg/mL)
P. tetrastromatica P1 13.0 ± 1.68 120.0 ± 0.97
P2 12.0 ± 2.01 138.5 ± 1.74
P3 15.0 ± 1.73 125.0 ± 0.91
C. racemosa P1 18.0 ± 1.43 105.0 ± 1.47
T. ornata P1 12.0 ± 2.35 110.5 ± 1.95
P2 22.0 ± 1.96 120.0 ± 1.47
  1. Cytotoxic activity is expressed as IC50 (μg/mL) ± SD (n = 3) and IC50 (μg/mL) ± SD (n = 3) for MCF-7 and 184B5 cells, respectively, which is the concentration of extract at which 50 % of cell growth was inhibited relative to cells incubated in the presence of 0.1 % DMSO vehicle control. MCF-7 and 184B5 cells were treated with doxorubicin as a positive control. The drug showed IC50 values at 0.21 ± 1.25 μg/ml and 0.02 ± 1.97 μg/ml in MCF-7 and 184B5 cells, respectively