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Table 1 Analysis of the correlation coefficient between various factors and neuropeptides

From: Electro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of Diarrhea-predominant irritable bowel syndrome(D-IBS)

Dependent Variables(Y) Predictors: (Constant)(X) R R Square Adjusted R Square Linear Regression(Y = B0 + B1X1 + B2X2 + … + BnXn) Model B Std. Error Beta t Sig.
body weight NPY in the colon, hypothalamus, spinal cord Excluded >0.05
body weight 5-HT in the colon, hypothalamus, spinal cord Excluded >0.05
body weight CGRP in the colon, hypothalamus, spinal cord Excluded >0.05
fecal pellets at 1 h X is CGRP in spinal cord 0.666 0.444 0.417 Y = −2.916 + 0.140X (Constant) −2.916 0.836   −3.489 0.001
CGRP of spinal cord 0.14 0.047 0.361 2.96 0.004
Excluded Variables: CGRP in the colon, hypothalamus CGRP of colon 0.105 0.06 0.195 1.749 0.085
CGRP of hypothalamus 0.076 0.04 0.239 1.92 0.059
fecal pellets at 1 h X1 is 5-HT of colon, X2 is 5-HT of spinal cord 0.588 0.345 0.325 Y = −2.005 + 0.013X1 + 0.012X2 (Constant) −2.005 0.806   −2.487 0.016
5-HT of colon 0.013 0.004 0.377 3.271 0.002
Excluded Variables: 5-HT of hypothalamus 5-HT of spinal cord 0.012 0.005 0.304 2.633 0.011
fecal pellets at 1 h X is NPY of spinal cord 0.568 0.322 0.29 Y = 9.619-0.003X (Constant) 9.619 1.332   7.221 <0.0001
NPY of spinal cord −0.003 0.001 −0.408 −3.762 <0.0001
Excluded Variables: NPY of colon, hypothalamus NPY of colon −0.001 0.001 −0.166 −1.421 0.16
NPY of hypothalamus 0 0.001 −0.18 −1.547 0.127
fecal pellets at 1 h X1is CGRP of spinal cord, X2 is NPY of spinal cord STEP EXCLUDED Y = 3.367 + 0.202X1-0.003X2 (Constant) 3.367 1.289   2.613 0.011
CGRP of spinal cord 0.202 0.035 0.521 5.809 <0.0001
NPY of spinal cord −0.003 0.001 −0.391 −4.363 <0.0001
Excluded Variables: 5-HT of colon, spinal cord, NPY of spinal cord 5-HT of spinal cord .258a 2.349 0.022 0.282 0.769
5-HT of colon .392a 4.267 0 0.471 0.928
NPY of spinal cord -.391a −4.363 0 −0.479 0.961
sacchar-intake amount X is CGRP of spinal cord 0.682 0.466 0.44 Y = 39.289-0.635X (Constant) 39.289 2.195   17.903 <0.0001
CGRP of spinal cord −0.635 0.124 −0.61 −5.105 <0.0001
Excluded Variables: CGRP of colon, hypothalamus CGRP of colon −0.234 0.158 −0.162 −1.478 0.144
CGRP of hypothalamus 0.024 0.104 0.029 0.235 0.815
sacchar-intake amount X is 5-HT of spinal cord 0.418 0.175 0.162 Y = 33.278-0.045X (Constant) 33.278 2.229   14.929 <0.0001
Excluded Variables: 5-HT of colon, hypothalamus 5-HT of spinal cord −0.045 0.012 −0.418 −3.711 <0.0001
sacchar-intake amount X1 is NPY of colon, X2 is NPY of hypothalamus 0.541 0.292 0.259 Y = 9.175 + 0.005X1 + 0.004X2 (Constant) 9.175 3.648   2.515 0.014
NPY of colon 0.005 0.002 0.279 2.336 0.023
Excluded Variables: NPY of spinal cord NPY of hypothalamus 0.004 0.002 0.271 2.275 0.026
NPY of spinal cord 0.004 0.003 0.171 1.544 0.128
sacchar-intake amount X is CGRP of spinal cord STEP EXCLUDED Y = 37.323-0.696X (Constant) 37.323 1.731   21.567 <0.0001
CGRP of spinal cord −0.696 0.096 −0.668 −7.245 <0.0001
Excluded Variables: 5-HT of spinal cord, NPY of hypothalamus, colon 5-HT of spinal cord –.126a −1.2 0.234 −0.148 0.769
NPY of hypothalamus .136a 1.285 0.203 0.159 0.755
NPY of colon .173a 1.701 0.094 0.208 0.798
AWR1 X is CGRP of spinal cord 0.556 0.309 0.299 Y = 0.624-0.015X (Constant) 0.624 0.05   12.403 <0.0001
CGRP of spinal cord −0.015 0.003 −0.556 −5.398 <0.0001
AWR2 X is CGRP of spinal cord 0.627 0.394 0.384 Y = 1.069-0.023X (Constant) 1.069 0.063   16.993 <0.0001
CGRP of spinal cord −0.023 0.003 −0.627 −6.494 <0.0001
AWR3 X is CGRP of spinal cord 0.657 0.432 0.423 Y = 1.48-0.03X (Constant) 1.48 0.076   19.557 <0.0001
CGRP of spinal cord −0.03 0.004 −0.657 −7.034 <0.0001
AWR4 X is CGRP of spinal cord 0.633 0.4 0.391 Y = 1.73-0.03X (Constant) 1.73 0.082   21.21 <0.0001
CGRP of spinal cord −0.03 0.005 −0.633 −6.585 <0.0001
AWR3 X is 5-HT of spinal cord 0.333 0.111 0.098 Y = 1.244-0.002X (Constant) 1.244 0.1   12.461 <0.0001
5-HT of spinal cord −0.002 0.001 −0.333 −2.851 0.006
AWR4 X is 5-HT of spinal cord 0.295 0.087 0.073 Y = 1.47-0.001X (Constant) 1.47 0.106   13.853 <0.0001
5-HT of spinal cord −0.001 0.001 −0.295 −2.49 0.015